Upregulated claudin‐1 expression confers resistance to cell death of nasopharyngeal carcinoma cells

• Published in: International journal of cancer Vol. 126; no. 6; pp. 1353 - 1366
• Main Authors: Lee, Jeng‐Woei, Hsiao, Wei‐Ting, Chen, Hsia‐Yun, Hsu, Lee‐Ping, Chen, Peir‐Rong, Lin, Ming‐Der, Chiu, Shu‐Jun, Shih, Wen‐Ling, Hsu, Yih‐Chih
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.03.2010; Wiley-Blackwell
• Subjects: Antimetabolites, Antineoplastic - pharmacology; apoptosis; Apoptosis - drug effects; Apoptosis - genetics; Biological and medical sciences; Blotting, Western; Cadherins - genetics; Cadherins - metabolism; Cell Line; Cell Line, Tumor; Cell Proliferation - drug effects; Claudin-1; Culture Media, Serum-Free - pharmacology; Drug Resistance, Neoplasm - genetics; E‐cadherin; Fluorouracil - pharmacology; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; Humans; Medical sciences; Membrane Proteins - genetics; Membrane Proteins - metabolism; Microscopy, Confocal; nasopharyngeal carcinoma; Nasopharyngeal Neoplasms - genetics; Nasopharyngeal Neoplasms - metabolism; Nasopharyngeal Neoplasms - pathology; NF-kappa B - metabolism; Oligonucleotide Array Sequence Analysis; Otorhinolaryngology. Stomatology; Proto-Oncogene Proteins c-akt - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction - drug effects; Tumors; Up-Regulation; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Claudin 1; nasopharyngeal carcinoma; Nasopharynx cancer; Cell adhesion molecule; Malignant tumor; Nasopharynx carcinoma; E-cadherin; Resistance; Cancerology; Cell death; ENT disease; Pharynx disease; claudin-1; E Cadherin; Cancer; Apoptosis

Accumulating evidence reveals that aberrant expression of claudins manifests in various tumors; however, their biological functions are poorly understood. Here, we report on the elevated expression of claudin‐1 in nasopharyngeal carcinoma (NPC) cell lines under serum deprivation or fluorouracil (5‐F...