Upregulated claudin‐1 expression confers resistance to cell death of nasopharyngeal carcinoma cells
Accumulating evidence reveals that aberrant expression of claudins manifests in various tumors; however, their biological functions are poorly understood. Here, we report on the elevated expression of claudin‐1 in nasopharyngeal carcinoma (NPC) cell lines under serum deprivation or fluorouracil (5‐F...
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| Published in | International journal of cancer Vol. 126; no. 6; pp. 1353 - 1366 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
15.03.2010
Wiley-Blackwell |
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| Online Access | Get full text |
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| Abstract | Accumulating evidence reveals that aberrant expression of claudins manifests in various tumors; however, their biological functions are poorly understood. Here, we report on the elevated expression of claudin‐1 in nasopharyngeal carcinoma (NPC) cell lines under serum deprivation or fluorouracil (5‐FU) treatment. Interestingly, an increase in expression of claudin‐1 considerably reduced apoptosis rather than enhancing cell proliferation. However, claudin‐1 expression and activity were unaffected by external stimuli or Akt and NF‐κB activation. Notably, predominant cytoplasmic and nuclear localization of claudin‐1 in NPC cells reflected the aforementioned feature. On the other hand, loss of epithelial morphology and E‐cadherin expression was associated with serum withdrawal in NPC cells. Interestingly, restoration of E‐cadherin inhibited the protein elevation and antiapoptotic activity of claudin‐1. In conclusion, our data demonstrate the regulation and novel biological function of claudin‐1 and indicate the important role of claudin‐1 in NPC tumorigenesis. |
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| AbstractList | Accumulating evidence reveals that aberrant expression of claudins manifests in various tumors; however, their biological functions are poorly understood. Here, we report on the elevated expression of claudin‐1 in nasopharyngeal carcinoma (NPC) cell lines under serum deprivation or fluorouracil (5‐FU) treatment. Interestingly, an increase in expression of claudin‐1 considerably reduced apoptosis rather than enhancing cell proliferation. However, claudin‐1 expression and activity were unaffected by external stimuli or Akt and NF‐κB activation. Notably, predominant cytoplasmic and nuclear localization of claudin‐1 in NPC cells reflected the aforementioned feature. On the other hand, loss of epithelial morphology and E‐cadherin expression was associated with serum withdrawal in NPC cells. Interestingly, restoration of E‐cadherin inhibited the protein elevation and antiapoptotic activity of claudin‐1. In conclusion, our data demonstrate the regulation and novel biological function of claudin‐1 and indicate the important role of claudin‐1 in NPC tumorigenesis. Accumulating evidence reveals that aberrant expression of claudins manifests in various tumors; however, their biological functions are poorly understood. Here, we report on the elevated expression of claudin-1 in nasopharyngeal carcinoma (NPC) cell lines under serum deprivation or fluorouracil (5-FU) treatment. Interestingly, an increase in expression of claudin-1 considerably reduced apoptosis rather than enhancing cell proliferation. However, claudin-1 expression and activity were unaffected by external stimuli or Akt and NF-kappaB activation. Notably, predominant cytoplasmic and nuclear localization of claudin-1 in NPC cells reflected the aforementioned feature. On the other hand, loss of epithelial morphology and E-cadherin expression was associated with serum withdrawal in NPC cells. Interestingly, restoration of E-cadherin inhibited the protein elevation and antiapoptotic activity of claudin-1. In conclusion, our data demonstrate the regulation and novel biological function of claudin-1 and indicate the important role of claudin-1 in NPC tumorigenesis.Accumulating evidence reveals that aberrant expression of claudins manifests in various tumors; however, their biological functions are poorly understood. Here, we report on the elevated expression of claudin-1 in nasopharyngeal carcinoma (NPC) cell lines under serum deprivation or fluorouracil (5-FU) treatment. Interestingly, an increase in expression of claudin-1 considerably reduced apoptosis rather than enhancing cell proliferation. However, claudin-1 expression and activity were unaffected by external stimuli or Akt and NF-kappaB activation. Notably, predominant cytoplasmic and nuclear localization of claudin-1 in NPC cells reflected the aforementioned feature. On the other hand, loss of epithelial morphology and E-cadherin expression was associated with serum withdrawal in NPC cells. Interestingly, restoration of E-cadherin inhibited the protein elevation and antiapoptotic activity of claudin-1. In conclusion, our data demonstrate the regulation and novel biological function of claudin-1 and indicate the important role of claudin-1 in NPC tumorigenesis. Accumulating evidence reveals that aberrant expression of claudins manifests in various tumors; however, their biological functions are poorly understood. Here, we report on the elevated expression of claudin-1 in nasopharyngeal carcinoma (NPC) cell lines under serum deprivation or fluorouracil (5-FU) treatment. Interestingly, an increase in expression of claudin-1 considerably reduced apoptosis rather than enhancing cell proliferation. However, claudin-1 expression and activity were unaffected by external stimuli or Akt and NF-kappaB activation. Notably, predominant cytoplasmic and nuclear localization of claudin-1 in NPC cells reflected the aforementioned feature. On the other hand, loss of epithelial morphology and E-cadherin expression was associated with serum withdrawal in NPC cells. Interestingly, restoration of E-cadherin inhibited the protein elevation and antiapoptotic activity of claudin-1. In conclusion, our data demonstrate the regulation and novel biological function of claudin-1 and indicate the important role of claudin-1 in NPC tumorigenesis. |
| Author | Chiu, Shu‐Jun Hsu, Yih‐Chih Shih, Wen‐Ling Chen, Peir‐Rong Lin, Ming‐Der Hsu, Lee‐Ping Lee, Jeng‐Woei Hsiao, Wei‐Ting Chen, Hsia‐Yun |
| Author_xml | – sequence: 1 givenname: Jeng‐Woei surname: Lee fullname: Lee, Jeng‐Woei email: jwlee@mail.tcu.edu.tw – sequence: 2 givenname: Wei‐Ting surname: Hsiao fullname: Hsiao, Wei‐Ting – sequence: 3 givenname: Hsia‐Yun surname: Chen fullname: Chen, Hsia‐Yun – sequence: 4 givenname: Lee‐Ping surname: Hsu fullname: Hsu, Lee‐Ping – sequence: 5 givenname: Peir‐Rong surname: Chen fullname: Chen, Peir‐Rong – sequence: 6 givenname: Ming‐Der surname: Lin fullname: Lin, Ming‐Der – sequence: 7 givenname: Shu‐Jun surname: Chiu fullname: Chiu, Shu‐Jun – sequence: 8 givenname: Wen‐Ling surname: Shih fullname: Shih, Wen‐Ling – sequence: 9 givenname: Yih‐Chih surname: Hsu fullname: Hsu, Yih‐Chih |
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| Keywords | Claudin 1 nasopharyngeal carcinoma Nasopharynx cancer Cell adhesion molecule Malignant tumor Nasopharynx carcinoma E-cadherin Resistance Cancerology Cell death ENT disease Pharynx disease claudin-1 E Cadherin Cancer Apoptosis |
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| SubjectTerms | Antimetabolites, Antineoplastic - pharmacology apoptosis Apoptosis - drug effects Apoptosis - genetics Biological and medical sciences Blotting, Western Cadherins - genetics Cadherins - metabolism Cell Line Cell Line, Tumor Cell Proliferation - drug effects Claudin-1 Culture Media, Serum-Free - pharmacology Drug Resistance, Neoplasm - genetics E‐cadherin Fluorouracil - pharmacology Gene Expression Profiling Gene Expression Regulation, Neoplastic Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans Medical sciences Membrane Proteins - genetics Membrane Proteins - metabolism Microscopy, Confocal nasopharyngeal carcinoma Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - pathology NF-kappa B - metabolism Oligonucleotide Array Sequence Analysis Otorhinolaryngology. Stomatology Proto-Oncogene Proteins c-akt - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - drug effects Tumors Up-Regulation Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| Title | Upregulated claudin‐1 expression confers resistance to cell death of nasopharyngeal carcinoma cells |
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