Sensitization in patients with painful knee osteoarthritis

• Published in: Pain (Amsterdam) Vol. 149; no. 3; pp. 573 - 581
• Main Authors: Arendt-Nielsen, Lars, Nie, Hongling, Laursen, Mogens B., Laursen, Birgitte S., Madeleine, Pascal, Simonsen, Ole H., Graven-Nielsen, Thomas
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier B.V 01.06.2010; Lippincott Williams & Wilkins, Inc; Elsevier
• Subjects: Arthralgia - diagnostic imaging; Arthralgia - etiology; Arthralgia - physiopathology; Biological and medical sciences; Disability Evaluation; Diseases of the osteoarticular system; Experimental pain; Female; Fundamental and applied biological sciences. Psychology; Humans; Illness and personality; Illness, stress and coping; Inhibition; Knee Joint - anatomy & histology; Knee Joint - innervation; Knee Joint - physiopathology; Knee osteoarthritis; Male; Medical sciences; Middle Aged; Muscle, Skeletal - innervation; Muscle, Skeletal - physiopathology; Osteoarthritis; Osteoarthritis, Knee - complications; Osteoarthritis, Knee - diagnostic imaging; Osteoarthritis, Knee - physiopathology; Pain Measurement - methods; Pain Threshold - physiology; Pressure pain threshold; Psychology and medicine; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Radiography; Sensitization; Severity of Illness Index; Temporal summation; Time Factors; Temporal summation; Experimental pain; Pressure pain threshold; Sensitization; Knee osteoarthritis; Inhibition; Facilitation; Knee; Human; Diffuse noxious inhibitory controls; Diseases of the osteoarticular system; Sex; Pain; Modulation; Extensor muscle; Arthropathy; Degenerative disease; Osteoarthritis
• ISSN: 0304-3959; 1872-6623; 1872-6623
• DOI: 10.1016/j.pain.2010.04.003

Pain is the dominant symptom in osteoarthritis (OA) and sensitization may contribute to the pain severity. This study investigated the role of sensitization in patients with painful knee OA by measuring (1) pressure pain thresholds (PPTs); (2) spreading sensitization; (3) temporal summation to repea...