Moderate liver impairment has no influence on daptomycin pharmacokinetics

• Published in: Journal of clinical pharmacology Vol. 44; no. 7; p. 715
• Main Author: Dvorchik, Barry
• Format: Journal Article
• Language: English
• Published: England 01.07.2004
• Subjects: Adult; Aged; Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - pharmacokinetics; Area Under Curve; Daptomycin - adverse effects; Daptomycin - pharmacokinetics; Female; Half-Life; Humans; Liver Diseases - complications; Liver Diseases - metabolism; Male; Metabolic Clearance Rate; Middle Aged

Daptomycin (N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine-lactone) is a novel cyclic lipopeptide antibiotic derived from the fermentation of Streptomyces roseosporus. Daptom...