The expression of MMP-2, MMP-7, MMP-9, and TIMP-1 in chronic rhinosinusitis and nasal polyposis

• Published in: Otolaryngology-head and neck surgery Vol. 139; no. 2; p. 211
• Main Authors: Can, Ilknur Haberal, Ceylan, Kursat, Caydere, Muzaffer, Samim, Ethem Erdal, Ustun, Huseyin, Karasoy, Durdu Sertkaya
• Format: Journal Article
• Language: English
• Published: England 01.08.2008
• Subjects: Adolescent; Adult; Aged; Chronic Disease; Female; Humans; Immunoenzyme Techniques; Male; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 7 - metabolism; Matrix Metalloproteinase 9 - metabolism; Middle Aged; Nasal Polyps - enzymology; Prospective Studies; Sinusitis - enzymology; Statistics, Nonparametric; Tissue Inhibitor of Metalloproteinase-1 - metabolism
• ISSN: 0194-5998
• DOI: 10.1016/j.otohns.2008.04.032

To investigate the expression and clinical significance of MMP-2, MMP-7, MMP-9, and TIMP-1 in patients with nasal polyposis (NP) and chronic rhinosinusitis (CRS). Prospective study. This study involved 54 patients. There were three groups: nasal polyposis group, chronic rhinosinusitis group, and control group. Specimens were collected during endoscopic sinus surgery. Each sample was immunohistochemically examined. Expression of MMP-2 was found significantly increased in NP, whereas MMP-7 expression was found significantly increased in CRS (P < 0.001). TIMP-1 was significantly high in control group compared to CRS and NP (P < 0.001 and P = 0.002, respectively). Different regulation type of activation of MMPs has been found in these two diseases. If MMP-2 expression is intense in the mucosa, then this ends with polyp formation; if MMP-7 expression is intense, it ends with CRS or stays as CRS.