Clinical characteristics and outcomes of phase I cancer patients with CCNE1 amplification: MD Anderson experiences

• Published in: Scientific reports Vol. 12; no. 1; p. 8701
• Main Authors: Yao, Shuyang, Meric-Bernstam, Funda, Hong, David, Janku, Filip, Naing, Aung, Piha-Paul, Sarina Anne, Tsimberidou, Apostolia Maria, Karp, Daniel, Subbiah, Vivek, Yap, Timothy Anthony, Ahnert, Jordi Rodon, Pant, Shubham, Dumbrava, Ecaterina E Ileana, Wathoo, Chetna, Campbell, Erick, Yu, Lihou, Yamamura, Yuko, Fu, Siqing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.05.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/337; 631/67; 692/4028; Angiogenesis; Body mass index; Clinical Trials, Phase I as Topic; Cyclin E; Cyclin E - genetics; Gene Amplification; Humanities and Social Sciences; Humans; Medical records; Metastases; Middle Aged; multidisciplinary; Mutation; Neoplasms - genetics; Oncogene Proteins - genetics; p53 Protein; Patients; Retrospective Studies; Science; Science (multidisciplinary); Solid tumors; Survival; Tumors

Cyclin E is frequently encoded by CCNE1 gene amplification in various malignancies. We reviewed the medical records of patients with solid tumors displaying CCNE1 amplification to determine the effect of this amplification for future therapeutic development. We reviewed the medical records of patien...