Telomere length was associated with grade and pathological features of meningioma

Telomeres are tandem repeats of the TTAGGG sequence at chromosomal ends and afford protection against chromosomal instability. To investigate the contribution of telomere dysfunction in meningiomas, here we estimate the associations between telomere length, tumor grade, and proliferation index in a...

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Published inScientific reports Vol. 12; no. 1; p. 6143
Main Authors Yamakawa, Keiko, Mukai, Yuri, Ye, Juanjuan, Muto-Ishizuka, Mariko, Ito, Masumi, Tanimoto, Misa, Suizu, Futoshi, Asano, Kenichiro, Kurose, Akira, Matsuda, Yoko
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 12.04.2022
Nature Publishing Group
Nature Portfolio
Subjects
631/67
692/4028
692/53
Brain cancer
Chromosomal Instability
Fluorescence in situ hybridization
Genomic instability
Humanities and Social Sciences
Humans
In Situ Hybridization, Fluorescence
Ki-67 Antigen - genetics
Meningeal Neoplasms - genetics
Meningeal Neoplasms - pathology
Meningioma
Meningioma - genetics
Meningioma - pathology
Mitosis
multidisciplinary
Nucleotide sequence
Science
Science (multidisciplinary)
Telomerase
Telomere - genetics
Telomere - pathology
Telomeres
Tumors
Yeast
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Abstract Telomeres are tandem repeats of the TTAGGG sequence at chromosomal ends and afford protection against chromosomal instability. To investigate the contribution of telomere dysfunction in meningiomas, here we estimate the associations between telomere length, tumor grade, and proliferation index in a series of 14 archived samples, using quantitative-fluorescence in situ hybridization, Ki67 immunostaining, and pathological analysis. The number of mitoses per 10 high-power fields (HPF) and Ki67 index was higher in grade III cases than in grade I or grade II cases. Telomere length was negatively associated with both the number of mitoses/10HPF and Ki67 index. Meningioma cases with atypical mitosis, a morphological marker of chromosomal instability, exhibited shortened telomeres. Among telomere-shortened meningioma cases, 40% were grade I, 20% were grade II, and 100% were grade III. In grade I or II meningiomas, shortened telomeres lacked high proliferation activity and atypical mitosis. In conclusion, telomere shortening might be pivotal in the development of high-grade meningioma. Analysis of telomere length might be a selective marker for meningiomas with high-grade malignant potential.
AbstractList Telomeres are tandem repeats of the TTAGGG sequence at chromosomal ends and afford protection against chromosomal instability. To investigate the contribution of telomere dysfunction in meningiomas, here we estimate the associations between telomere length, tumor grade, and proliferation index in a series of 14 archived samples, using quantitative-fluorescence in situ hybridization, Ki67 immunostaining, and pathological analysis. The number of mitoses per 10 high-power fields (HPF) and Ki67 index was higher in grade III cases than in grade I or grade II cases. Telomere length was negatively associated with both the number of mitoses/10HPF and Ki67 index. Meningioma cases with atypical mitosis, a morphological marker of chromosomal instability, exhibited shortened telomeres. Among telomere-shortened meningioma cases, 40% were grade I, 20% were grade II, and 100% were grade III. In grade I or II meningiomas, shortened telomeres lacked high proliferation activity and atypical mitosis. In conclusion, telomere shortening might be pivotal in the development of high-grade meningioma. Analysis of telomere length might be a selective marker for meningiomas with high-grade malignant potential.
Abstract Telomeres are tandem repeats of the TTAGGG sequence at chromosomal ends and afford protection against chromosomal instability. To investigate the contribution of telomere dysfunction in meningiomas, here we estimate the associations between telomere length, tumor grade, and proliferation index in a series of 14 archived samples, using quantitative-fluorescence in situ hybridization, Ki67 immunostaining, and pathological analysis. The number of mitoses per 10 high-power fields (HPF) and Ki67 index was higher in grade III cases than in grade I or grade II cases. Telomere length was negatively associated with both the number of mitoses/10HPF and Ki67 index. Meningioma cases with atypical mitosis, a morphological marker of chromosomal instability, exhibited shortened telomeres. Among telomere-shortened meningioma cases, 40% were grade I, 20% were grade II, and 100% were grade III. In grade I or II meningiomas, shortened telomeres lacked high proliferation activity and atypical mitosis. In conclusion, telomere shortening might be pivotal in the development of high-grade meningioma. Analysis of telomere length might be a selective marker for meningiomas with high-grade malignant potential.
Abstract Telomeres are tandem repeats of the TTAGGG sequence at chromosomal ends and afford protection against chromosomal instability. To investigate the contribution of telomere dysfunction in meningiomas, here we estimate the associations between telomere length, tumor grade, and proliferation index in a series of 14 archived samples, using quantitative-fluorescence in situ hybridization, Ki67 immunostaining, and pathological analysis. The number of mitoses per 10 high-power fields (HPF) and Ki67 index was higher in grade III cases than in grade I or grade II cases. Telomere length was negatively associated with both the number of mitoses/10HPF and Ki67 index. Meningioma cases with atypical mitosis, a morphological marker of chromosomal instability, exhibited shortened telomeres. Among telomere-shortened meningioma cases, 40% were grade I, 20% were grade II, and 100% were grade III. In grade I or II meningiomas, shortened telomeres lacked high proliferation activity and atypical mitosis. In conclusion, telomere shortening might be pivotal in the development of high-grade meningioma. Analysis of telomere length might be a selective marker for meningiomas with high-grade malignant potential.
ArticleNumber 6143
Author Ye, Juanjuan
Mukai, Yuri
Yamakawa, Keiko
Kurose, Akira
Tanimoto, Misa
Suizu, Futoshi
Ito, Masumi
Asano, Kenichiro
Muto-Ishizuka, Mariko
Matsuda, Yoko
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Snippet Telomeres are tandem repeats of the TTAGGG sequence at chromosomal ends and afford protection against chromosomal instability. To investigate the contribution...
Abstract Telomeres are tandem repeats of the TTAGGG sequence at chromosomal ends and afford protection against chromosomal instability. To investigate the...
Abstract Telomeres are tandem repeats of the TTAGGG sequence at chromosomal ends and afford protection against chromosomal instability. To investigate the...
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StartPage 6143
SubjectTerms 631/67
692/4028
692/53
Brain cancer
Chromosomal Instability
Fluorescence in situ hybridization
Genomic instability
Humanities and Social Sciences
Humans
In Situ Hybridization, Fluorescence
Ki-67 Antigen - genetics
Meningeal Neoplasms - genetics
Meningeal Neoplasms - pathology
Meningioma
Meningioma - genetics
Meningioma - pathology
Mitosis
multidisciplinary
Nucleotide sequence
Science
Science (multidisciplinary)
Telomerase
Telomere - genetics
Telomere - pathology
Telomeres
Tumors
Yeast
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Title Telomere length was associated with grade and pathological features of meningioma
URI https://link.springer.com/article/10.1038/s41598-022-10157-4
https://www.ncbi.nlm.nih.gov/pubmed/35414715
https://www.proquest.com/docview/2649432246
https://search.proquest.com/docview/2649996984
https://pubmed.ncbi.nlm.nih.gov/PMC9005517
https://doaj.org/article/f1402bf9aac44e3f83799669a6f65ef9
Volume 12
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