Benzodiazepine-induced spatial learning deficits in rats are regulated by the degree of modulation of α1 GABAA receptors

• Published in: European neuropsychopharmacology Vol. 23; no. 5; pp. 390 - 399
• Main Authors: Joksimović, Srđan, Divljaković, Jovana, Van Linn, Michael L, Varagic, Zdravko, Brajković, Gordana, Milinković, Marija M, Yin, Wenyuan, Timić, Tamara, Sieghart, Werner, Cook, James M, Savić, Miroslav M
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.05.2013
• Subjects: Diazepam; GABAA subtype selective ligand; Internal Medicine; Psychiatry; Two electrode voltage clamp; Water maze; GABA A subtype selective ligand; Two electrode voltage clamp; Diazepam; Water maze; GABAA subtype selective ligand

Abstract Despite significant advances in understanding the role of benzodiazepine (BZ)-sensitive populations of GABAA receptors, containing the α1 , α2 , α3 or α5 subunit, factual substrates of BZ-induced learning and memory deficits are not yet fully elucidated. It was shown that α1 -subunit affini...