Capacity of adult and prepubertal mouse oocytes to undergo embryo development in the presence of cysteamine

• Published in: Molecular reproduction and development Vol. 64; no. 2; pp. 214 - 218
• Main Authors: de Matos, D.G., Nogueira, D., Cortvrindt, R., Herrera, C., Adriaenssens, T., Pasqualini, R.S., Smitz, J.
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.02.2003; Wiley-Liss
• Subjects: Animals; Biological and medical sciences; Buthionine Sulfoximine - pharmacology; Cysteamine - pharmacology; embryo development; Embryo, Mammalian - drug effects; Embryo, Mammalian - embryology; Embryo, Mammalian - metabolism; Enzyme Inhibitors - pharmacology; Fundamental and applied biological sciences. Psychology; glutathione; IVF; IVM; low molecular weigh thiols; Mammalian female genital system; Mice; Morphology. Physiology; Oocytes - drug effects; Oocytes - metabolism; Radiation-Protective Agents - pharmacology; Vertebrates: reproduction; Culture medium; Embryonic development; IVM; Thiol; low molecular weigh thiols; Mercaptamine; Rodentia; embryo development; Germinal cell; Vertebrata; Mammalia; Mouse; Prepuberty; IVF; Oocyte; Glutathione; Oocyte maturation

The present study was carried out to study de novo glutathione (GSH) synthesis and to evaluate the effect of stimulating GSH synthesis during in vitro maturation (IVM) of adult and prepubertal mouse oocytes on the embryo developmental rate. Adult (8 weeks old) and prepubertal mice (24–26 days old) w...