Erythrocyte and the Regulation of Human Skeletal Muscle Blood Flow and Oxygen Delivery: Role of Circulating ATP

• Published in: Circulation research Vol. 91; no. 11; pp. 1046 - 1055
• Main Authors: González-Alonso, José, Olsen, David B., Saltin, Bengt
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 29.11.2002; Lippincott; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: Adenosine Triphosphate - administration & dosage; Adenosine Triphosphate - blood; Adenosine Triphosphate - physiology; Administration, Inhalation; Adult; Biological and medical sciences; Blood Flow Velocity - drug effects; Blood Flow Velocity - physiology; Carbon Monoxide - pharmacology; Carboxyhemoglobin - analysis; Carboxyhemoglobin - metabolism; Erythrocytes - physiology; Female; Femoral Artery - physiology; Fundamental and applied biological sciences. Psychology; Hemoglobins - analysis; Hemoglobins - metabolism; Humans; Hyperoxia - metabolism; Hypoxia - metabolism; Infusions, Intra-Arterial; Leg - blood supply; Leg - physiology; Male; Muscle, Skeletal - blood supply; Muscle, Skeletal - physiology; Oxygen - metabolism; Oxygen Consumption - physiology; Physical Exertion - physiology; Reference Values; Regional Blood Flow - drug effects; Regional Blood Flow - physiology; Striated muscle. Tendons; Vertebrates: osteoarticular system, musculoskeletal system; Physical exercise; Knee; Human; Red blood cell; Oxygen transfer; Environmental factor; Striated muscle; Blood flow; skeletal muscle blood flow; Blood cell; Regulation(control); erythrocytes; Extensor muscle; oxygen delivery; oxygen sensor; Hemodynamics; ATP
• ISSN: 0009-7330; 1524-4571; 1524-4571
• DOI: 10.1161/01.RES.0000044939.73286.E2

ABSTRACT—Blood flow to contracting skeletal muscle is tightly coupled to the oxygenation state of hemoglobin. To investigate if ATP could be a signal by which the erythrocyte contributes to the regulation of skeletal muscle blood flow and oxygen (O2) delivery, we measured circulating ATP in 8 young...