Selective optogenetic control of Gq signaling using human Neuropsin

Abstract G q proteins are universally important for signal transduction in mammalian cells. The underlying kinetics and transformation from extracellular stimuli into intracellular signaling, however could not be investigated in detail so far. Here we present the human Neuropsin (hOPN5) for specific...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 13; no. 1; p. 1765
Main Authors Wagdi, Ahmed, Malan, Daniela, Sathyanarayanan, Udhayabhaskar, Beauchamp, Janosch S., Vogt, Markus, Zipf, David, Beiert, Thomas, Mansuroglu, Berivan, Dusend, Vanessa, Meininghaus, Mark, Schneider, Linn, Kalthof, Bernd, Wiegert, J. Simon, König, Gabriele M., Kostenis, Evi, Patejdl, Robert, Sasse, Philipp, Bruegmann, Tobias
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group 01.04.2022
Nature Publishing Group UK
Nature Portfolio
Subjects
Animal models
Calcium ions
Channel gating
Genetic transformation
High-throughput screening
Intestine
Intracellular signalling
Kinetics
Mammalian cells
Pharmacology
Potassium channels (inwardly-rectifying)
Proteins
Screening
Signal transduction
Signaling
Small intestine
Temporal resolution
Transgenic animals
Ultraviolet radiation
Online AccessGet full text

Cover

Abstract Abstract G q proteins are universally important for signal transduction in mammalian cells. The underlying kinetics and transformation from extracellular stimuli into intracellular signaling, however could not be investigated in detail so far. Here we present the human Neuropsin (hOPN5) for specific and repetitive manipulation of G q signaling in vitro and in vivo with high spatio-temporal resolution. Properties and G protein specificity of hOPN5 are characterized by UV light induced IP 3 generation, Ca 2+ transients and inhibition of G IRK channel activity in HEK cells. In adult hearts from a transgenic animal model, light increases the spontaneous beating rate. In addition, we demonstrate light induced contractions in the small intestine, which are not detectable after pharmacological G q protein block. All-optical high-throughput screening for TRPC6 inhibitors is more specific and sensitive than conventional pharmacological screening. Thus, we demonstrate specific G q signaling of hOPN5 and unveil its potential for optogenetic applications.
AbstractList Gq proteins are universally important for signal transduction in mammalian cells. The underlying kinetics and transformation from extracellular stimuli into intracellular signaling, however could not be investigated in detail so far. Here we present the human Neuropsin (hOPN5) for specific and repetitive manipulation of Gq signaling in vitro and in vivo with high spatio-temporal resolution. Properties and G protein specificity of hOPN5 are characterized by UV light induced IP3 generation, Ca2+ transients and inhibition of GIRK channel activity in HEK cells. In adult hearts from a transgenic animal model, light increases the spontaneous beating rate. In addition, we demonstrate light induced contractions in the small intestine, which are not detectable after pharmacological Gq protein block. All-optical high-throughput screening for TRPC6 inhibitors is more specific and sensitive than conventional pharmacological screening. Thus, we demonstrate specific Gq signaling of hOPN5 and unveil its potential for optogenetic applications.Gq proteins are one of four major classes of G proteins; optogenetic receptors for selective and repetitive activation of Gq proteins with fast kinetics are lacking. Here the authors report UV light-dependent Gq signalling using human Neuropsin (hOPN5) and demonstrate its potential as an optogenetic tool.
G q proteins are universally important for signal transduction in mammalian cells. The underlying kinetics and transformation from extracellular stimuli into intracellular signaling, however could not be investigated in detail so far. Here we present the human Neuropsin (hOPN5) for specific and repetitive manipulation of G q signaling in vitro and in vivo with high spatio-temporal resolution. Properties and G protein specificity of hOPN5 are characterized by UV light induced IP 3 generation, Ca 2+ transients and inhibition of G IRK channel activity in HEK cells. In adult hearts from a transgenic animal model, light increases the spontaneous beating rate. In addition, we demonstrate light induced contractions in the small intestine, which are not detectable after pharmacological G q protein block. All-optical high-throughput screening for TRPC6 inhibitors is more specific and sensitive than conventional pharmacological screening. Thus, we demonstrate specific G q signaling of hOPN5 and unveil its potential for optogenetic applications. Gq proteins are one of four major classes of G proteins; optogenetic receptors for selective and repetitive activation of Gq proteins with fast kinetics are lacking. Here the authors report UV light-dependent Gq signalling using human Neuropsin (hOPN5) and demonstrate its potential as an optogenetic tool.
Gq proteins are one of four major classes of G proteins; optogenetic receptors for selective and repetitive activation of Gq proteins with fast kinetics are lacking. Here the authors report UV light-dependent Gq signalling using human Neuropsin (hOPN5) and demonstrate its potential as an optogenetic tool.
Abstract G q proteins are universally important for signal transduction in mammalian cells. The underlying kinetics and transformation from extracellular stimuli into intracellular signaling, however could not be investigated in detail so far. Here we present the human Neuropsin (hOPN5) for specific and repetitive manipulation of G q signaling in vitro and in vivo with high spatio-temporal resolution. Properties and G protein specificity of hOPN5 are characterized by UV light induced IP 3 generation, Ca 2+ transients and inhibition of G IRK channel activity in HEK cells. In adult hearts from a transgenic animal model, light increases the spontaneous beating rate. In addition, we demonstrate light induced contractions in the small intestine, which are not detectable after pharmacological G q protein block. All-optical high-throughput screening for TRPC6 inhibitors is more specific and sensitive than conventional pharmacological screening. Thus, we demonstrate specific G q signaling of hOPN5 and unveil its potential for optogenetic applications.
ArticleNumber 1765
Author Meininghaus, Mark
Dusend, Vanessa
Patejdl, Robert
Sathyanarayanan, Udhayabhaskar
Wiegert, J. Simon
Schneider, Linn
Beauchamp, Janosch S.
Malan, Daniela
König, Gabriele M.
Wagdi, Ahmed
Zipf, David
Beiert, Thomas
Vogt, Markus
Kostenis, Evi
Kalthof, Bernd
Sasse, Philipp
Mansuroglu, Berivan
Bruegmann, Tobias
Author_xml – sequence: 1
  givenname: Ahmed
  orcidid: 0000-0002-7952-9307
  surname: Wagdi
  fullname: Wagdi, Ahmed
– sequence: 2
  givenname: Daniela
  surname: Malan
  fullname: Malan, Daniela
– sequence: 3
  givenname: Udhayabhaskar
  surname: Sathyanarayanan
  fullname: Sathyanarayanan, Udhayabhaskar
– sequence: 4
  givenname: Janosch S.
  surname: Beauchamp
  fullname: Beauchamp, Janosch S.
– sequence: 5
  givenname: Markus
  surname: Vogt
  fullname: Vogt, Markus
– sequence: 6
  givenname: David
  surname: Zipf
  fullname: Zipf, David
– sequence: 7
  givenname: Thomas
  surname: Beiert
  fullname: Beiert, Thomas
– sequence: 8
  givenname: Berivan
  surname: Mansuroglu
  fullname: Mansuroglu, Berivan
– sequence: 9
  givenname: Vanessa
  orcidid: 0000-0001-7561-0178
  surname: Dusend
  fullname: Dusend, Vanessa
– sequence: 10
  givenname: Mark
  orcidid: 0000-0003-0388-2128
  surname: Meininghaus
  fullname: Meininghaus, Mark
– sequence: 11
  givenname: Linn
  surname: Schneider
  fullname: Schneider, Linn
– sequence: 12
  givenname: Bernd
  surname: Kalthof
  fullname: Kalthof, Bernd
– sequence: 13
  givenname: J. Simon
  orcidid: 0000-0003-0893-9349
  surname: Wiegert
  fullname: Wiegert, J. Simon
– sequence: 14
  givenname: Gabriele M.
  surname: König
  fullname: König, Gabriele M.
– sequence: 15
  givenname: Evi
  orcidid: 0000-0001-8284-5514
  surname: Kostenis
  fullname: Kostenis, Evi
– sequence: 16
  givenname: Robert
  surname: Patejdl
  fullname: Patejdl, Robert
– sequence: 17
  givenname: Philipp
  orcidid: 0000-0002-8502-9472
  surname: Sasse
  fullname: Sasse, Philipp
– sequence: 18
  givenname: Tobias
  orcidid: 0000-0002-6930-9634
  surname: Bruegmann
  fullname: Bruegmann, Tobias
BookMark eNpdkU1r3DAQhkVJaNI0f6AnQy-9uJVH35dCWdI0EJJD2rOQ5LHjxWttJDtL_32VOJSmOkjD6OFhpPcdOZrihIR8aOjnhjL9JfOGS1VTgBoMSFEf3pBToLypGwXs6J_6hJznvKVlMdNozt-SEyaYFJLKU7K5wxHDPDxiFfdz7HHCeQhViNOc4ljFrrp8qPLQT24cpr5a8tN-v-zcVN3gkuK-NN6T486NGc9fzjPy6_vFz82P-vr28mrz7boOXPBDzcC0GFAYrTsErQQobZQWKnRUMBCyFZ1pFdOgmELjPLTeM-elAOSd6tgZuVq9bXRbu0_DzqXfNrrBPjdi6q1LZfoRrQNlPFcq8I5zKbynHkC0zgfjHTWuuL6urv3id9gGLO914yvp65tpuLd9fLRlZGGYLIJPL4IUHxbMs90NOeA4ugnjki1ILg3TVPGCfvwP3cYllR9dqRKhNlAoWKmQYs4Ju7_DNNQ-RW7XyG3h7XPk9sD-ALoUnzU
CitedBy_id crossref_primary_10_1016_j_jbc_2023_105020
crossref_primary_10_1113_JP281930
crossref_primary_10_1038_s41598_023_28476_5
crossref_primary_10_1002_adom_202202248
crossref_primary_10_7554_eLife_83974
crossref_primary_10_1007_s11427_022_2122_0
crossref_primary_10_1146_annurev_vision_100820_094018
crossref_primary_10_1016_j_jmb_2023_168319
crossref_primary_10_1089_hum_2022_236
crossref_primary_10_1016_j_isci_2022_105828
crossref_primary_10_3389_fphys_2022_1031062
crossref_primary_10_1038_s41592_024_02285_8
crossref_primary_10_1142_S1793545822300130
crossref_primary_10_1007_s00424_023_02892_y
crossref_primary_10_1371_journal_pone_0284824
crossref_primary_10_3390_nu15061406
crossref_primary_10_1007_s11427_022_2150_1
crossref_primary_10_1016_j_molmet_2022_101552
crossref_primary_10_1007_s00424_023_02879_9
crossref_primary_10_3390_cells12172167
crossref_primary_10_1007_s00424_022_02765_w
Cites_doi 10.1084/jem.20181895
10.1074/jbc.M110.147298
10.1016/j.cellsig.2014.01.010
10.1074/jbc.M113.514075
10.1038/s41467-019-09124-x
10.1016/j.tips.2013.10.008
10.1016/j.neuron.2014.01.041
10.1038/nature07926
10.1126/science.1203535
10.1038/s42003-019-0292-y
10.1111/j.1748-1716.1987.tb08269.x
10.1111/bjd.19797
10.1371/journal.pone.0026388
10.1371/journal.pone.0030774
10.1073/pnas.1516259112
10.3389/fphys.2020.00170
10.1124/mi.2.3.168
10.7150/thno.53883
10.1021/cn400062a
10.1152/ajpcell.00237.2005
10.1038/s41467-019-09322-7
10.1113/expphysiol.2010.055517
10.1007/s00018-016-2405-9
10.1038/sj.onc.1202173
10.1097/FJC.0b013e3181e1d263
10.1038/nmeth.1512
10.1073/pnas.1006393107
10.1074/jbc.M109.098517
10.1016/j.yjmcc.2009.03.020
10.1073/pnas.1012498107
10.1002/cbic.201900110
10.1016/j.bbrc.2019.12.117
10.1016/j.cub.2014.05.038
10.1016/0090-6980(78)90149-1
10.1124/mol.117.111062
10.1155/2016/3969023
10.1038/s41422-018-0049-z
10.1016/j.cub.2016.03.007
10.1111/bph.13151
10.1161/CIRCRESAHA.111.243824
10.1007/3-540-45103-X_50
10.1038/s41586-020-2683-0
10.1158/1541-7786.MCR-17-0007
10.1007/s00424-020-02387-0
10.1038/ncomms10156
10.1111/micc.12293
10.1093/cvr/cvu046
10.1074/jbc.REV119.007061
10.1016/0014-2999(87)90609-1
10.1016/j.pbiomolbio.2021.07.007
10.1016/S0014-5793(03)01212-2
10.1038/srep05352
10.1126/science.1071550
10.1016/j.cellsig.2005.08.004
10.1038/s41598-019-53875-y
10.1186/s12915-017-0380-8
10.1371/journal.pbio.1002143
10.1016/S0090-6980(79)80059-3
10.1111/php.12354
10.1091/mbc.e04-10-0883
10.1152/physrev.00003.2005
10.1186/1471-2164-12-14
10.1038/nchembio.2007.17
10.1016/j.cub.2019.08.063
10.1021/jm5019093
10.2741/4421
10.1074/jbc.M111.253674
10.1073/pnas.1220697110
10.1038/nmeth.1808
10.1126/sciadv.abc9675
10.1038/s41598-017-14330-y
10.1039/c4pp00361f
10.1016/j.tips.2018.01.001
10.1371/journal.pcbi.1007857
ContentType Journal Article
Copyright The Author(s) 2022. corrected publication 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
The Author(s) 2022
Copyright_xml – notice: The Author(s) 2022. corrected publication 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: The Author(s) 2022
DBID AAYXX
CITATION
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/s41467-022-29265-w
DatabaseName CrossRef
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni Edition)
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Database‎ (1962 - current)
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
ProQuest Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Biological Science Database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest - Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
Directory of Open Access Journals
DatabaseTitle CrossRef
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
Health Research Premium Collection
Natural Science Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
Technology Collection
Technology Research Database
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Publicly Available Content Database


CrossRef
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 1765
ExternalDocumentID oai_doaj_org_article_a279b477c4f4465bb0b225dabc9ba09a
10_1038_s41467_022_29265_w
GrantInformation_xml – fundername: ;
– fundername: ;
  grantid: Promotionsstipendium
– fundername: ;
  grantid: 200857327; 200857327; 214362475; 214362475; 214362475; 214362475; 315402240; 313904155; 380524518; 200857327; 214362475; 315212873; 93793266; EXC 2067/1-390729940
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
AAYXX
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADRAZ
AENEX
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
CITATION
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PQEST
PQUKI
PRINS
RC3
SOI
7X8
AFGXO
5PM
AAADF
ZA5
ID FETCH-LOGICAL-c454w-329dece5988fe287527897857cf053256d5f9d7382737e9ab2dbb3ab652e4f7f3
IEDL.DBID RPM
ISSN 2041-1723
IngestDate Thu Jul 04 21:10:16 EDT 2024
Tue Sep 17 21:24:21 EDT 2024
Fri Aug 16 07:39:30 EDT 2024
Fri Sep 13 08:47:20 EDT 2024
Fri Aug 23 02:30:27 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c454w-329dece5988fe287527897857cf053256d5f9d7382737e9ab2dbb3ab652e4f7f3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0003-0388-2128
0000-0002-6930-9634
0000-0003-0893-9349
0000-0001-7561-0178
0000-0001-8284-5514
0000-0002-8502-9472
0000-0002-7952-9307
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975936/
PMID 35365606
PQID 2646022892
PQPubID 546298
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_a279b477c4f4465bb0b225dabc9ba09a
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8975936
proquest_miscellaneous_2646938074
proquest_journals_2646022892
crossref_primary_10_1038_s41467_022_29265_w
PublicationCentury 2000
PublicationDate 20220401
PublicationDateYYYYMMDD 2022-04-01
PublicationDate_xml – month: 4
  year: 2022
  text: 20220401
  day: 1
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
PublicationTitle Nature communications
PublicationYear 2022
Publisher Nature Publishing Group
Nature Publishing Group UK
Nature Portfolio
Publisher_xml – name: Nature Publishing Group
– name: Nature Publishing Group UK
– name: Nature Portfolio
References U Ferrari (29265_CR25) 2020; 16
SR Neves (29265_CR1) 2002; 296
NI Amobi (29265_CR61) 1987; 135
M Vogt (29265_CR68) 2021; 11
JL Dahlin (29265_CR51) 2015; 58
V Chua (29265_CR14) 2017; 15
R Schrage (29265_CR45) 2015; 6
29265_CR74
Y Nakane (29265_CR37) 2014; 24
F Richter (29265_CR72) 2015; 14
A Mery (29265_CR53) 2005; 16
T Yamashita (29265_CR34) 2014; 289
K Becker (29265_CR76) 2019; 9
R Sharif-Naeini (29265_CR8) 2010; 48
SA Tennigkeit (29265_CR47) 2019; 20
WK Karunarathne (29265_CR18) 2013; 110
YK Ju (29265_CR56) 2011; 109
H Ye (29265_CR32) 2011; 332
CJ Simon (29265_CR24) 2020; 527
W Wang (29265_CR17) 2018; 39
K Haltaufderhyde (29265_CR40) 2015; 91
RK Sunahara (29265_CR58) 2002; 2
KB Hubbard (29265_CR10) 2006; 18
YSM Mederos (29265_CR16) 2016; 23
MH Berry (29265_CR66) 2019; 10
LA Gundelach (29265_CR67) 2020; 472
Y Lan (29265_CR60) 2021; 185
J Wietek (29265_CR65) 2017; 7
K Sriram (29265_CR3) 2018; 93
EE Tarttelin (29265_CR36) 2003; 554
N Sjoblom (29265_CR63) 1987; 131
RD Airan (29265_CR33) 2009; 458
T Sugiyama (29265_CR44) 2014; 4
AM Lyon (29265_CR6) 2014; 35
D Jing (29265_CR75) 2018; 28
D Kamato (29265_CR2) 2017; 74
M van Wyk (29265_CR23) 2015; 13
MA Kirschenbaum (29265_CR15) 1979; 18
TM Jang (29265_CR69) 2020; 6
Y Nakane (29265_CR38) 2010; 107
HJ Bailes (29265_CR30) 2012; 7
T Yamashita (29265_CR35) 2010; 107
EA MacDonald (29265_CR55) 2020; 11
T Beiert (29265_CR22) 2014; 102
S Mishra (29265_CR57) 2010; 56
ED Buhr (29265_CR42) 2019; 29
29265_CR54
Y Hisano (29265_CR46) 2019; 216
TD O’Connell (29265_CR73) 2007; 357
J Inglese (29265_CR49) 2007; 3
L Zhang (29265_CR12) 2016; 2016
OA Masseck (29265_CR27) 2014; 81
D Kojima (29265_CR39) 2011; 6
E Oh (29265_CR26) 2010; 285
DV Gutierrez (29265_CR28) 2011; 286
HJ Bailes (29265_CR31) 2013; 280
S Kleinlogel (29265_CR5) 2016; 21
ED Buhr (29265_CR41) 2015; 112
GM Laekeman (29265_CR62) 1978; 15
BK Atwood (29265_CR59) 2011; 12
KX Zhang (29265_CR43) 2020; 585
T Bruegmann (29265_CR52) 2010; 7
E Kostenis (29265_CR13) 2020; 295
T Maier (29265_CR50) 2015; 172
OA Masseck (29265_CR7) 2011; 96
G Sanchez-Fernandez (29265_CR9) 2014; 26
N Wettschureck (29265_CR4) 2005; 85
M Maier-Peuschel (29265_CR70) 2010; 285
P Makowka (29265_CR21) 2019; 10
J Mattis (29265_CR64) 2011; 9
S Offermanns (29265_CR11) 1998; 17
HJ Bailes (29265_CR20) 2017; 15
K Kaufmann (29265_CR71) 2013; 4
K Spoida (29265_CR19) 2016; 26
D Eickelbeck (29265_CR29) 2019; 2
GE Breitwieser (29265_CR48) 2005; 289
References_xml – volume: 216
  start-page: 1582
  year: 2019
  ident: 29265_CR46
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20181895
  contributor:
    fullname: Y Hisano
– volume: 285
  start-page: 30825
  year: 2010
  ident: 29265_CR26
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.147298
  contributor:
    fullname: E Oh
– volume: 26
  start-page: 833
  year: 2014
  ident: 29265_CR9
  publication-title: Cell Signal.
  doi: 10.1016/j.cellsig.2014.01.010
  contributor:
    fullname: G Sanchez-Fernandez
– volume: 289
  start-page: 3991
  year: 2014
  ident: 29265_CR34
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M113.514075
  contributor:
    fullname: T Yamashita
– volume: 10
  year: 2019
  ident: 29265_CR66
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-09124-x
  contributor:
    fullname: MH Berry
– volume: 35
  start-page: 23
  year: 2014
  ident: 29265_CR6
  publication-title: Trends Pharmacol. Sci.
  doi: 10.1016/j.tips.2013.10.008
  contributor:
    fullname: AM Lyon
– volume: 81
  start-page: 1263
  year: 2014
  ident: 29265_CR27
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.01.041
  contributor:
    fullname: OA Masseck
– volume: 458
  start-page: 1025
  year: 2009
  ident: 29265_CR33
  publication-title: Nature
  doi: 10.1038/nature07926
  contributor:
    fullname: RD Airan
– volume: 332
  start-page: 1565
  year: 2011
  ident: 29265_CR32
  publication-title: Science
  doi: 10.1126/science.1203535
  contributor:
    fullname: H Ye
– volume: 2
  start-page: 60
  year: 2019
  ident: 29265_CR29
  publication-title: Commun. Biol.
  doi: 10.1038/s42003-019-0292-y
  contributor:
    fullname: D Eickelbeck
– volume: 131
  start-page: 499
  year: 1987
  ident: 29265_CR63
  publication-title: Acta Physiol. Scand.
  doi: 10.1111/j.1748-1716.1987.tb08269.x
  contributor:
    fullname: N Sjoblom
– volume: 185
  start-page: 391
  year: 2021
  ident: 29265_CR60
  publication-title: Br. J. Dermatol.
  doi: 10.1111/bjd.19797
  contributor:
    fullname: Y Lan
– volume: 6
  start-page: e26388
  year: 2011
  ident: 29265_CR39
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0026388
  contributor:
    fullname: D Kojima
– volume: 7
  start-page: e30774
  year: 2012
  ident: 29265_CR30
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0030774
  contributor:
    fullname: HJ Bailes
– volume: 112
  start-page: 13093
  year: 2015
  ident: 29265_CR41
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1516259112
  contributor:
    fullname: ED Buhr
– volume: 11
  start-page: 170
  year: 2020
  ident: 29265_CR55
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2020.00170
  contributor:
    fullname: EA MacDonald
– volume: 2
  start-page: 168
  year: 2002
  ident: 29265_CR58
  publication-title: Mol. Interv.
  doi: 10.1124/mi.2.3.168
  contributor:
    fullname: RK Sunahara
– volume: 11
  start-page: 5569
  year: 2021
  ident: 29265_CR68
  publication-title: Theranostics
  doi: 10.7150/thno.53883
  contributor:
    fullname: M Vogt
– volume: 4
  start-page: 1278
  year: 2013
  ident: 29265_CR71
  publication-title: ACS Chem. Neurosci.
  doi: 10.1021/cn400062a
  contributor:
    fullname: K Kaufmann
– volume: 289
  start-page: C509
  year: 2005
  ident: 29265_CR48
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00237.2005
  contributor:
    fullname: GE Breitwieser
– volume: 10
  year: 2019
  ident: 29265_CR21
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-09322-7
  contributor:
    fullname: P Makowka
– volume: 96
  start-page: 51
  year: 2011
  ident: 29265_CR7
  publication-title: Exp. Physiol.
  doi: 10.1113/expphysiol.2010.055517
  contributor:
    fullname: OA Masseck
– volume: 74
  start-page: 1379
  year: 2017
  ident: 29265_CR2
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-016-2405-9
  contributor:
    fullname: D Kamato
– volume: 17
  start-page: 1375
  year: 1998
  ident: 29265_CR11
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1202173
  contributor:
    fullname: S Offermanns
– volume: 56
  start-page: 598
  year: 2010
  ident: 29265_CR57
  publication-title: J. Cardiovasc. Pharmacol.
  doi: 10.1097/FJC.0b013e3181e1d263
  contributor:
    fullname: S Mishra
– volume: 7
  start-page: 897
  year: 2010
  ident: 29265_CR52
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1512
  contributor:
    fullname: T Bruegmann
– volume: 107
  start-page: 15264
  year: 2010
  ident: 29265_CR38
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1006393107
  contributor:
    fullname: Y Nakane
– volume: 285
  start-page: 8793
  year: 2010
  ident: 29265_CR70
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109.098517
  contributor:
    fullname: M Maier-Peuschel
– volume: 48
  start-page: 83
  year: 2010
  ident: 29265_CR8
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2009.03.020
  contributor:
    fullname: R Sharif-Naeini
– volume: 107
  start-page: 22084
  year: 2010
  ident: 29265_CR35
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1012498107
  contributor:
    fullname: T Yamashita
– volume: 20
  start-page: 1766
  year: 2019
  ident: 29265_CR47
  publication-title: Chembiochem
  doi: 10.1002/cbic.201900110
  contributor:
    fullname: SA Tennigkeit
– volume: 527
  start-page: 325
  year: 2020
  ident: 29265_CR24
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2019.12.117
  contributor:
    fullname: CJ Simon
– volume: 24
  start-page: R596
  year: 2014
  ident: 29265_CR37
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2014.05.038
  contributor:
    fullname: Y Nakane
– volume: 15
  start-page: 829
  year: 1978
  ident: 29265_CR62
  publication-title: Prostaglandins
  doi: 10.1016/0090-6980(78)90149-1
  contributor:
    fullname: GM Laekeman
– volume: 93
  start-page: 251
  year: 2018
  ident: 29265_CR3
  publication-title: Mol. Pharmacol.
  doi: 10.1124/mol.117.111062
  contributor:
    fullname: K Sriram
– volume: 2016
  start-page: 3969023
  year: 2016
  ident: 29265_CR12
  publication-title: J. Immunol. Res.
  doi: 10.1155/2016/3969023
  contributor:
    fullname: L Zhang
– volume: 28
  start-page: 803
  year: 2018
  ident: 29265_CR75
  publication-title: Cell Res.
  doi: 10.1038/s41422-018-0049-z
  contributor:
    fullname: D Jing
– volume: 26
  start-page: 1206
  year: 2016
  ident: 29265_CR19
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2016.03.007
  contributor:
    fullname: K Spoida
– volume: 172
  start-page: 3650
  year: 2015
  ident: 29265_CR50
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/bph.13151
  contributor:
    fullname: T Maier
– volume: 109
  start-page: 848
  year: 2011
  ident: 29265_CR56
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.111.243824
  contributor:
    fullname: YK Ju
– ident: 29265_CR74
  doi: 10.1007/3-540-45103-X_50
– volume: 585
  start-page: 420
  year: 2020
  ident: 29265_CR43
  publication-title: Nature
  doi: 10.1038/s41586-020-2683-0
  contributor:
    fullname: KX Zhang
– volume: 15
  start-page: 501
  year: 2017
  ident: 29265_CR14
  publication-title: Mol. Cancer Res.
  doi: 10.1158/1541-7786.MCR-17-0007
  contributor:
    fullname: V Chua
– volume: 472
  start-page: 527
  year: 2020
  ident: 29265_CR67
  publication-title: Pflug. Arch.
  doi: 10.1007/s00424-020-02387-0
  contributor:
    fullname: LA Gundelach
– volume: 6
  year: 2015
  ident: 29265_CR45
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms10156
  contributor:
    fullname: R Schrage
– volume: 23
  start-page: 621
  year: 2016
  ident: 29265_CR16
  publication-title: Microcirculation
  doi: 10.1111/micc.12293
  contributor:
    fullname: YSM Mederos
– volume: 102
  start-page: 507
  year: 2014
  ident: 29265_CR22
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvu046
  contributor:
    fullname: T Beiert
– volume: 295
  start-page: 5206
  year: 2020
  ident: 29265_CR13
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.REV119.007061
  contributor:
    fullname: E Kostenis
– volume: 135
  start-page: 173
  year: 1987
  ident: 29265_CR61
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/0014-2999(87)90609-1
  contributor:
    fullname: NI Amobi
– ident: 29265_CR54
  doi: 10.1016/j.pbiomolbio.2021.07.007
– volume: 554
  start-page: 410
  year: 2003
  ident: 29265_CR36
  publication-title: FEBS Lett.
  doi: 10.1016/S0014-5793(03)01212-2
  contributor:
    fullname: EE Tarttelin
– volume: 4
  year: 2014
  ident: 29265_CR44
  publication-title: Sci. Rep.
  doi: 10.1038/srep05352
  contributor:
    fullname: T Sugiyama
– volume: 296
  start-page: 1636
  year: 2002
  ident: 29265_CR1
  publication-title: Science
  doi: 10.1126/science.1071550
  contributor:
    fullname: SR Neves
– volume: 18
  start-page: 135
  year: 2006
  ident: 29265_CR10
  publication-title: Cell Signal.
  doi: 10.1016/j.cellsig.2005.08.004
  contributor:
    fullname: KB Hubbard
– volume: 9
  year: 2019
  ident: 29265_CR76
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-019-53875-y
  contributor:
    fullname: K Becker
– volume: 15
  year: 2017
  ident: 29265_CR20
  publication-title: BMC Biol.
  doi: 10.1186/s12915-017-0380-8
  contributor:
    fullname: HJ Bailes
– volume: 13
  start-page: e1002143
  year: 2015
  ident: 29265_CR23
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.1002143
  contributor:
    fullname: M van Wyk
– volume: 18
  start-page: 401
  year: 1979
  ident: 29265_CR15
  publication-title: Prostaglandins
  doi: 10.1016/S0090-6980(79)80059-3
  contributor:
    fullname: MA Kirschenbaum
– volume: 91
  start-page: 117
  year: 2015
  ident: 29265_CR40
  publication-title: Photochem. Photobiol.
  doi: 10.1111/php.12354
  contributor:
    fullname: K Haltaufderhyde
– volume: 16
  start-page: 2414
  year: 2005
  ident: 29265_CR53
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e04-10-0883
  contributor:
    fullname: A Mery
– volume: 85
  start-page: 1159
  year: 2005
  ident: 29265_CR4
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00003.2005
  contributor:
    fullname: N Wettschureck
– volume: 12
  year: 2011
  ident: 29265_CR59
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-12-14
  contributor:
    fullname: BK Atwood
– volume: 3
  start-page: 466
  year: 2007
  ident: 29265_CR49
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.2007.17
  contributor:
    fullname: J Inglese
– volume: 29
  start-page: 3478
  year: 2019
  ident: 29265_CR42
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2019.08.063
  contributor:
    fullname: ED Buhr
– volume: 58
  start-page: 2091
  year: 2015
  ident: 29265_CR51
  publication-title: J. Med. Chem.
  doi: 10.1021/jm5019093
  contributor:
    fullname: JL Dahlin
– volume: 21
  start-page: 794
  year: 2016
  ident: 29265_CR5
  publication-title: Front. Biosci.
  doi: 10.2741/4421
  contributor:
    fullname: S Kleinlogel
– volume: 286
  start-page: 25848
  year: 2011
  ident: 29265_CR28
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.253674
  contributor:
    fullname: DV Gutierrez
– volume: 110
  start-page: E1565
  year: 2013
  ident: 29265_CR18
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1220697110
  contributor:
    fullname: WK Karunarathne
– volume: 9
  start-page: 159
  year: 2011
  ident: 29265_CR64
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1808
  contributor:
    fullname: J Mattis
– volume: 6
  start-page: eabc9675
  year: 2020
  ident: 29265_CR69
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abc9675
  contributor:
    fullname: TM Jang
– volume: 357
  start-page: 271
  year: 2007
  ident: 29265_CR73
  publication-title: Methods Mol. Biol.
  contributor:
    fullname: TD O’Connell
– volume: 280
  start-page: 20122987
  year: 2013
  ident: 29265_CR31
  publication-title: Proc. Biol. Sci.
  contributor:
    fullname: HJ Bailes
– volume: 7
  year: 2017
  ident: 29265_CR65
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-14330-y
  contributor:
    fullname: J Wietek
– volume: 14
  start-page: 270
  year: 2015
  ident: 29265_CR72
  publication-title: Photochem. Photobiol. Sci.
  doi: 10.1039/c4pp00361f
  contributor:
    fullname: F Richter
– volume: 39
  start-page: 367
  year: 2018
  ident: 29265_CR17
  publication-title: Trends Pharmacol. Sci.
  doi: 10.1016/j.tips.2018.01.001
  contributor:
    fullname: W Wang
– volume: 16
  start-page: e1007857
  year: 2020
  ident: 29265_CR25
  publication-title: PLoS Comput. Biol.
  doi: 10.1371/journal.pcbi.1007857
  contributor:
    fullname: U Ferrari
SSID ssj0000391844
Score 2.528113
Snippet Abstract G q proteins are universally important for signal transduction in mammalian cells. The underlying kinetics and transformation from extracellular...
Gq proteins are universally important for signal transduction in mammalian cells. The underlying kinetics and transformation from extracellular stimuli into...
G q proteins are universally important for signal transduction in mammalian cells. The underlying kinetics and transformation from extracellular stimuli into...
Gq proteins are one of four major classes of G proteins; optogenetic receptors for selective and repetitive activation of Gq proteins with fast kinetics are...
SourceID doaj
pubmedcentral
proquest
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
StartPage 1765
SubjectTerms Animal models
Calcium ions
Channel gating
Genetic transformation
High-throughput screening
Intestine
Intracellular signalling
Kinetics
Mammalian cells
Pharmacology
Potassium channels (inwardly-rectifying)
Proteins
Screening
Signal transduction
Signaling
Small intestine
Temporal resolution
Transgenic animals
Ultraviolet radiation
SummonAdditionalLinks – databaseName: Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8QwEA6yIHgRn1hdJYI3Ka7N-6jiA0EvKngLSZuol3Z1d1n8986kddmevHhNeki_mSTfkJlvCDmpRjo4oXguvdQ5l6XLnWEhZwHYCCsFhABY7_zwKO9e-P2reF1q9YU5Ya08cAvcmSuU8VypkkfU9vJ-5MEFK-dL493ItNToXCwFU-kMZgZCF95VyYyYPpvwdCZg8nphCinyee8mSoL9PZbZz5FcunRuNsh6xxbpRbvKTbIS6i2y2vaP_N4mV0-piw0cWLQZTxvwBSxJpF36OW0ivf2kmKHhsOicYo77G01d-WgS5RjDwA55ubl-vrrLu64IeckFn-esMFXA4imtY4B4R2Atq9JClRG7PAhZiWgqxTQQExWM80XlPXNeiiLwqCLbJYO6qcMeoQ4iadjTqpJAAmMUQGGN0A7QC7E6jzEjp78I2XErfmHTozXTtsXTAp424WnnGblEEBdfonB1GgBz2s6c9i9zZmT4awLb7aaJBdImUafHFBk5XkzDPsDHDVeHZtZ-Y1A9n2dE9UzXW1B_pv54T4raACB2Ntz_jz84IGsFelnK7hmSwfRrFg6BuEz9UfLRH-Oa7QY
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1NixQxEC3WFcGL-Imtq0TwJmFm852T6OI6CHrRhbmFpDtZvXTP7s4y-O-tSveM9sVrEuimUqm8JFXvAbztli5HbRU3yTiuTBt59DJzmRGNyFbjEYDqnb9-M6sL9WWt10ew2tfCUFrlPibWQN0NLd2RL3DjNsTV4sUiJroFaLeL95srTvpR9M46iWncgbunAmEFerZd28NtC_GgO6WmqpmldIsbVWMEJbMLL4zmu9nOVAn8Z6hznjP5zyZ0_hAeTOiRfRin-xEc5f4x3Bv1JH8_gbPvVdUGAxgbNtsBfYNKFNmUjs6Gwj5fMcrYiFSEzijn_ZJVlT5WSTo22PAULs4__Thb8UklgbdKqx2XwneZiqmcKxnPP5pqW63Tti2k-qBNp4vvrHQIVGz2MYkuJRmT0SKrYot8Bsf90OfnwCKerHGN284gKCxFI6T12kW0Xi7daSkNvNtbKGxGMoxQH7GlC6M9A9ozVHuGXQMfyYiHkURkXRuG68swrYsQhfVJWduqQtRtKS0TRpguptanuPSxgZP9FIRpdd2Ev77QwJtDN64LeuyIfR5uxzGe2PRVA3Y2dbMfmvf0v35Whm00ICkdvvj_x1_CfUH-U_N4TuB4e32bXyFE2abX1fv-AD0E53w
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3PaxUxEB5qRelF6i9cbUsEb7L6zO8cRLTYFqFe9EFvIdlNWkF2X19fefa_dya7r7jQk9dkA8uXmeQbMvMNwJt2ZlNQRtY6altL3YQ6OJFqkZCNiEZhCED1zqff9clcfjtTZ1uwaXc0Anh1Z2hH_aTmy9_v_lzefEKH_ziUjNv3V7K4O-Wlc8e1qtf34D6XQpLFn450v5zMwmFAI8fambuX7sBDoQRJ0ujJVVUU_Sc0dJpE-c-tdLQLj0Y6yT4P-_8YtlL3BB4MDSZvnsLhj9LmBk801i9WPRoL1SyyMT-d9ZkdXzJK4QhUlc4oCf6clbZ9rKh2LHDgGcyPvv48PKnHtgl1I5Vc14K7NlF1lbU5YUCkqNjVWGWaTG0glG5Vdq0RFpmLSS5E3sYoQtSKJ5lNFs9hu-u79AJYwFAbnd60Gllizgo5rlM2IJAptx9yruDtBiG_GNQxfHnVFtYP0HqE1hdo_bqCLwTi7ZekbF0G-uW5Hx3FB25clMY0MpOWW4yziEdOG2LjYpi5UMHeZgv8xlo8sjpNQj6OV_D6dhodhV4_Qpf66-EbR_L6sgIz2brJD01nul8XRXIbAaTWhy__e-Ur2OFkZSXnZw-2V8vrtI90ZhUPio3-BRsq9KI
  priority: 102
  providerName: Scholars Portal
Title Selective optogenetic control of Gq signaling using human Neuropsin
URI https://www.proquest.com/docview/2646022892/abstract/
https://search.proquest.com/docview/2646938074
https://pubmed.ncbi.nlm.nih.gov/PMC8975936
https://doaj.org/article/a279b477c4f4465bb0b225dabc9ba09a
Volume 13
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swED_6wUZfRrsP5rULGuxtuMms78c0NC2BlLKukDch2VJXWO2sTQn773uSnVK_9sUGSQZxOp3urN_9DuB7NVLecsly4YTKmShtbjX1OfXojdCSYwgQ853nF-L8ms0WfLEFfJMLk0D7pbs9rv_eHde3fxK2cnlXDjc4seHlfKK0jIXohtuwLSl9EaIn80s1Ri2sS5AZUTV8YMkcRNx6oQvB8_UevKWcRt4Z0TuPEm1_z9fsIyVfHD3TfXjX-Yxk3M7tALZ8_R7etFUk_3-AyVWqZYNmizTLVYMaERMTSQdCJ00gZ_9IxGnYmHpOItL9hqTafCRRcyyx4SNcT09_T87zrjZCXjLO1jktdOVjCpVSwWPUw2NGq1RcliHWeuCi4kFXkip0T6TX1hWVc9Q6wQvPggz0E-zUTe0_A7EYT-POlpVAVzAEjo6s5sqiIH2ofoaQwY-NhMyypcAw6eqaKtOK1qBoTRKtWWdwEoX4PDLSV6eG5v7GdItobCG1Y1KWLETCNudGDu1KZV2pnR1pm8HRZglMt6ceDLpuIrL16CKDb8_duBviFYetffPYjtGRQ59lIHtL15tQvwfVLPFqd2r15dVfHsJeEbUsAXuOYGd1_-i_os-ycgPU1IXEp5qeDWB3PJ5dzfB9cnpx-WuQ_gPgc87UIOnyEzv4858
link.rule.ids 230,315,733,786,790,870,891,2115,12083,12792,21416,24346,27957,27958,31754,31755,33408,33409,33779,33780,43345,43635,43840,53827,53829,74102,74392,74659
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Nb9QwEB1BEYIL4lMEChiJG7K6xN8nBBVlgbYXWmlvlh3bLZdk291qxb_H43gXcuFqW0o0Ho_H9pv3AN6FmY5OKE6ll5py2TnqDIuUxZyNsE7kIwDWO5-cyvk5_74Qi3rhtqqwym1MLIE6DB3ekR_kjVsiV4tpPy6vKKpG4etqldC4DXc4YxwhfWqhdncsyH6uOa-1MjOmD1a8RAaEsLemlYJuJvtRoe2f5JpTpOQ_W8_RQ3hQc0byaZzkR3Ar9o_h7qgi-fsJHP4sWjY5bJFhuR6yR2BhIqkgdDIk8vWKIE7DYek5QaT7BSnafKRQcyxzw1M4P_pydjinVRuBdlzwDWWtCRFLqLROMZ96BFa0Ki1Ul1DrQcggkgmK6ZyeqGicb4P3zHkp2siTSuwZ7PVDH58Dcfk8nVe2CjKngimJnMgaoV22XkzhQ0oNvN9ayC5HCgxbnq6ZtqM9bbanLfa0mwY-oxF3I5G-ujQM1xe2rgbrWmU8V6rjCQnbvJ_5HFeC853xbmZcA_vbKbB1Ta3sXw9o4O2uO68GfOJwfRxuxjEGOfR5A2oydZMfmvb0vy4Lr3Y2IOobvvj_x9_AvfnZybE9_nb64yXcb9GXCpJnH_bW1zfxVU5S1v518cQ_KNrmrw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagFYhLxVMNLWAkbijaJX6fEC1dymtVAZV6s-zYLlySbXerFf-eGce7kAtX21Ki8Xg8tr_5PkJehamOTiheSy91zWXramdYrFmEbIS1Ao4AWO_8dS5Pz_mnC3FR8E_LAqvcxMQcqEPf4h35BDZuiVwtppmkAos4ez97u7iqUUEKX1qLnMZtsqu4FODhu0cn87Nv2xsX5ELXnJfKmSnTkyXPcQIB7Y1ppKjXo90pk_iPMs8xbvKfjWh2n-yVDJK-G6b8AbkVu4fkzqAp-fsROf6elW0giNF-serBP7BMkRZIOu0T_XBFEbXhsBCdIu79kmalPpqJOhbQ8Jicz05-HJ_WRSmhbrng65o1JkQsqNI6RTgDCaxvVVqoNqHyg5BBJBMU05CsqGicb4L3zHkpmsiTSuwJ2en6Lu4T6uB0DetcBQmJYUoC0lojtAPrxRTepFSR1xsL2cVAiGHzQzbTdrCnBXvabE-7rsgRGnE7Esmsc0N_fWnL2rCuUcZzpVqekL7N-6mHKBOcb413U-MqcriZAltW2NL-9YeKvNx2w9rABw_Xxf5mGGOQUZ9XRI2mbvRD457u18_Msg0GRLXDp___-AtyF9zQfvk4_3xA7jXoShnWc0h2Vtc38RlkLCv_vLjiH9S67FI
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Selective+optogenetic+control+of+Gq+signaling+using+human+Neuropsin&rft.jtitle=Nature+communications&rft.au=Wagdi%2C+Ahmed&rft.au=Malan%2C+Daniela&rft.au=Sathyanarayanan%2C+Udhayabhaskar&rft.au=Beauchamp%2C+Janosch+S.&rft.date=2022-04-01&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2041-1723&rft.volume=13&rft_id=info:doi/10.1038%2Fs41467-022-29265-w&rft_id=info%3Apmid%2F35365606&rft.externalDBID=PMC8975936
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon