Hepatoprotective effects of capsaicin and alpha-tocopherol on mitochondrial function in mice fed a high-fat diet
Capsaicin (CAP) and alpha-tocopherol (TOC) have antioxidant properties. We investigated effects of CAP and TOC on mitochondrial oxidative stress and mitochondrial bioenergetics in liver of mice fed HFD. AST, ALT, glucose, homeostasis model assessment-insulin resistance index ((HOMA-IR)) and mitochon...
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Published in | Biomedicine & pharmacotherapy Vol. 98; pp. 821 - 825 |
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Format | Journal Article |
Language | English |
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01.02.2018
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Abstract | Capsaicin (CAP) and alpha-tocopherol (TOC) have antioxidant properties. We investigated effects of CAP and TOC on mitochondrial oxidative stress and mitochondrial bioenergetics in liver of mice fed HFD. AST, ALT, glucose, homeostasis model assessment-insulin resistance index ((HOMA-IR)) and mitochondrial oxidative stress parameters increased, whereas oxidative phosphorylation (OXPHOS) enzymes, tricarboxylic acid cycle (TCA) enzymes, ATP level and mitochondrial metabolic function (MTT) decreased in mice fed a HFD compared to the fed a standard diet (NC). Treatment of HFD together with CAP (HFC group), TOC (HFT group) or TOC and CAP (HCT group) can ameliorate the examined parameters. Because co-treatment with CAP and TOC displayed a better ameliorating effect on liver redox status and mitochondrial bioenergetics functions, they can be useful to protect against HFD and oxidative stress-related in liver diseases. |
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AbstractList | Capsaicin (CAP) and alpha-tocopherol (TOC) have antioxidant properties. We investigated effects of CAP and TOC on mitochondrial oxidative stress and mitochondrial bioenergetics in liver of mice fed HFD. AST, ALT, glucose, homeostasis model assessment-insulin resistance index ((HOMA-IR)) and mitochondrial oxidative stress parameters increased, whereas oxidative phosphorylation (OXPHOS) enzymes, tricarboxylic acid cycle (TCA) enzymes, ATP level and mitochondrial metabolic function (MTT) decreased in mice fed a HFD compared to the fed a standard diet (NC). Treatment of HFD together with CAP (HFC group), TOC (HFT group) or TOC and CAP (HCT group) can ameliorate the examined parameters. Because co-treatment with CAP and TOC displayed a better ameliorating effect on liver redox status and mitochondrial bioenergetics functions, they can be useful to protect against HFD and oxidative stress-related in liver diseases. |
Author | Şekeroğlu, Vedat Atlı Şekeroğlu, Zülal Özdener Kömpe, Yasemin Aydın, Birsen |
Author_xml | – sequence: 1 givenname: Vedat surname: Şekeroğlu fullname: Şekeroğlu, Vedat email: sekerogluv@hotmail.com organization: Department of Molecular Biology and Genetics, Faculty of Science and Letters, Ordu University, 52200 Ordu, Turkey – sequence: 2 givenname: Birsen surname: Aydın fullname: Aydın, Birsen organization: Department of Biology, Faculty of Science and Letters, Amasya University, 05100 Amasya, Turkey – sequence: 3 givenname: Zülal surname: Atlı Şekeroğlu fullname: Atlı Şekeroğlu, Zülal organization: Department of Molecular Biology and Genetics, Faculty of Science and Letters, Ordu University, 52200 Ordu, Turkey – sequence: 4 givenname: Yasemin surname: Özdener Kömpe fullname: Özdener Kömpe, Yasemin organization: Department of Biology, Faculty of Science and Letters, Ondokuz Mayıs University, 55139 Samsun, Turkey |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29571252$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1071_AN20439 crossref_primary_10_3390_nu12082433 crossref_primary_10_1039_D0FO01467B crossref_primary_10_1007_s00210_024_03092_w crossref_primary_10_2478_aiht_2022_73_3640 crossref_primary_10_1111_ijfs_15063 crossref_primary_10_3390_nu10050630 crossref_primary_10_1002_ptr_7660 crossref_primary_10_3390_ani12223180 crossref_primary_10_1080_13813455_2021_1962913 crossref_primary_10_1248_bpb_b19_00668 crossref_primary_10_1016_j_heliyon_2023_e14205 crossref_primary_10_1080_21655979_2022_2031399 crossref_primary_10_1016_j_jpba_2019_112837 crossref_primary_10_1080_15376516_2023_2301357 crossref_primary_10_1039_D3FO03727D |
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Keywords | Mitochondria Alpha-tocopherol Capsaicin Liver High fat diet |
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Snippet | Capsaicin (CAP) and alpha-tocopherol (TOC) have antioxidant properties. We investigated effects of CAP and TOC on mitochondrial oxidative stress and... |
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SubjectTerms | Alpha-tocopherol Capsaicin High fat diet Liver Mitochondria |
Title | Hepatoprotective effects of capsaicin and alpha-tocopherol on mitochondrial function in mice fed a high-fat diet |
URI | https://dx.doi.org/10.1016/j.biopha.2018.01.026 https://www.ncbi.nlm.nih.gov/pubmed/29571252 https://search.proquest.com/docview/2018029843 |
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