Hepatoprotective effects of capsaicin and alpha-tocopherol on mitochondrial function in mice fed a high-fat diet
Capsaicin (CAP) and alpha-tocopherol (TOC) have antioxidant properties. We investigated effects of CAP and TOC on mitochondrial oxidative stress and mitochondrial bioenergetics in liver of mice fed HFD. AST, ALT, glucose, homeostasis model assessment-insulin resistance index ((HOMA-IR)) and mitochon...
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| Published in | Biomedicine & pharmacotherapy Vol. 98; pp. 821 - 825 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Masson SAS
01.02.2018
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| Abstract | Capsaicin (CAP) and alpha-tocopherol (TOC) have antioxidant properties. We investigated effects of CAP and TOC on mitochondrial oxidative stress and mitochondrial bioenergetics in liver of mice fed HFD. AST, ALT, glucose, homeostasis model assessment-insulin resistance index ((HOMA-IR)) and mitochondrial oxidative stress parameters increased, whereas oxidative phosphorylation (OXPHOS) enzymes, tricarboxylic acid cycle (TCA) enzymes, ATP level and mitochondrial metabolic function (MTT) decreased in mice fed a HFD compared to the fed a standard diet (NC). Treatment of HFD together with CAP (HFC group), TOC (HFT group) or TOC and CAP (HCT group) can ameliorate the examined parameters. Because co-treatment with CAP and TOC displayed a better ameliorating effect on liver redox status and mitochondrial bioenergetics functions, they can be useful to protect against HFD and oxidative stress-related in liver diseases. |
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| AbstractList | Capsaicin (CAP) and alpha-tocopherol (TOC) have antioxidant properties. We investigated effects of CAP and TOC on mitochondrial oxidative stress and mitochondrial bioenergetics in liver of mice fed HFD. AST, ALT, glucose, homeostasis model assessment-insulin resistance index ((HOMA-IR)) and mitochondrial oxidative stress parameters increased, whereas oxidative phosphorylation (OXPHOS) enzymes, tricarboxylic acid cycle (TCA) enzymes, ATP level and mitochondrial metabolic function (MTT) decreased in mice fed a HFD compared to the fed a standard diet (NC). Treatment of HFD together with CAP (HFC group), TOC (HFT group) or TOC and CAP (HCT group) can ameliorate the examined parameters. Because co-treatment with CAP and TOC displayed a better ameliorating effect on liver redox status and mitochondrial bioenergetics functions, they can be useful to protect against HFD and oxidative stress-related in liver diseases. |
| Author | Şekeroğlu, Vedat Atlı Şekeroğlu, Zülal Özdener Kömpe, Yasemin Aydın, Birsen |
| Author_xml | – sequence: 1 givenname: Vedat surname: Şekeroğlu fullname: Şekeroğlu, Vedat email: sekerogluv@hotmail.com organization: Department of Molecular Biology and Genetics, Faculty of Science and Letters, Ordu University, 52200 Ordu, Turkey – sequence: 2 givenname: Birsen surname: Aydın fullname: Aydın, Birsen organization: Department of Biology, Faculty of Science and Letters, Amasya University, 05100 Amasya, Turkey – sequence: 3 givenname: Zülal surname: Atlı Şekeroğlu fullname: Atlı Şekeroğlu, Zülal organization: Department of Molecular Biology and Genetics, Faculty of Science and Letters, Ordu University, 52200 Ordu, Turkey – sequence: 4 givenname: Yasemin surname: Özdener Kömpe fullname: Özdener Kömpe, Yasemin organization: Department of Biology, Faculty of Science and Letters, Ondokuz Mayıs University, 55139 Samsun, Turkey |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29571252$$D View this record in MEDLINE/PubMed |
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| Keywords | Mitochondria Alpha-tocopherol Capsaicin Liver High fat diet |
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| SubjectTerms | Alpha-tocopherol Capsaicin High fat diet Liver Mitochondria |
| Title | Hepatoprotective effects of capsaicin and alpha-tocopherol on mitochondrial function in mice fed a high-fat diet |
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