Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

• Published in: Science (American Association for the Advancement of Science) Vol. 352; no. 6284; pp. 459 - 463
• Main Authors: Mackay, Laura K., Minnich, Martina, Kragten, Natasja A. M., Liao, Yang, Nota, Benjamin, Seillet, Cyril, Zaid, Ali, Man, Kevin, Preston, Simon, Freestone, David, Braun, Asolina, Wynne-Jones, Erica, Behr, Felix M., Stark, Regina, Pellicci, Daniel G., Godfrey, Dale I., Belz, Gabrielle T., Pellegrini, Marc, Gebhardt, Thomas, Busslinger, Meinrad, Shi, Wei, Carbone, Francis R., van Lier, René A. W., Kallies, Axel, van Gisbergen, Klaas P. J. M.
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 22.04.2016; The American Association for the Advancement of Science
• Subjects: Animals; Cellular biology; Gastrointestinal Tract - immunology; Gene Expression Regulation; Genes, Regulator - genetics; Genes, Regulator - physiology; Immune system; Immunologic Memory - genetics; Kidney - immunology; Killer Cells, Natural - immunology; Liver - immunology; Lymphocyte Activation; Lymphocytes; Mice; Mice, Knockout; Natural Killer T-Cells - immunology; Pathogens; Positive Regulatory Domain I-Binding Factor 1; Retention; Skin - immunology; Tissues; Transcription Factors - genetics; Transcription Factors - physiology; Transcription, Genetic; Up-Regulation

Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptio...