MicroRNA-7, a Homeobox D10 Target, Inhibits p21-Activated Kinase 1 and Regulates Its Functions

• Published in: Cancer research (Chicago, Ill.) Vol. 68; no. 20; pp. 8195 - 8200
• Main Authors: Reddy, Sirigiri Divijendra Natha, Ohshiro, Kazufumi, Rayala, Suresh K., Kumar, Rakesh
• Format: Journal Article
• Language: English
• Published: United States 15.10.2008
• Subjects: 3' Untranslated Regions - physiology; Adaptor Proteins, Signal Transducing - analysis; Breast Neoplasms - pathology; Cell Line, Tumor; Cell Movement; ErbB Receptors - analysis; Female; Gene Expression Regulation; Homeodomain Proteins - physiology; Humans; Insulin Receptor Substrate Proteins; MicroRNAs - genetics; MicroRNAs - physiology; Neoplasm Invasiveness; p21-Activated Kinases - analysis; p21-Activated Kinases - antagonists & inhibitors; p21-Activated Kinases - genetics; p21-Activated Kinases - physiology; Promoter Regions, Genetic; Transcription Factors - physiology

MicroRNAs are noncoding RNAs that inhibit the expression of their targets in a sequence-specific manner and play crucial roles during oncogenesis. Here we show that microRNA-7 (miR-7) inhibits p21-activated kinase 1 (Pak1) expression, a widely up-regulated signaling kinase in multiple human cancers,...