Gastrointestinal stromal tumors (GISTs) of the colon

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. Although they may arise anywhere of GI tract, colonic presentation is infrequent. We report 2 new cases of colonic GISTs localized at descending and sigmoid colon. Endoscopic biopsies w...

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Published inRevista española de enfermedades digestivas Vol. 102; no. 6; pp. 388 - 390
Main Authors Macías-García, F, Parada, P, Martínez-Lesquereux, L, Pintos, E, Fraga, M, Domínguez-Muñoz, J E
Format Journal Article
LanguageEnglish
Portuguese
Published Spain Sociedad Española de Patología Digestiva 01.06.2010
Subjects
Aged
Aged, 80 and over
Colonic Neoplasms - diagnosis
Colonic Neoplasms - surgery
Female
Gastroenterology & Hepatology
Gastrointestinal Stromal Tumors - diagnosis
Gastrointestinal Stromal Tumors - surgery
Geriatrics & Gerontology
Humans
Infectious Diseases
Male
Oncology
Pathology
Pharmacology & Pharmacy
Radiology, Nuclear Medicine & Medical Imaging
Surgery
GIST
Gastrointestinal stromal tumors
Colon
Tumores del estroma gastrointestinal
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Summary:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. Although they may arise anywhere of GI tract, colonic presentation is infrequent. We report 2 new cases of colonic GISTs localized at descending and sigmoid colon. Endoscopic biopsies were diagnostic for GISTs and no distant metastasis were observed. Both cases underwent resective surgery as the only treatment. No recurrence was observed during the follow-up period. In this clinical note we review the diagnosis, management and therapeutical options in colonic GISTs, according to literature. KIT immunoreactivity is the base for diagnosis. Risk of malignancy is based on the primary tumor diameter and the mitotic count. Anatomic localization is not an independent prognostic factor. Surgery is the standard treatment for localized primary disease and imatinib is indicated if metastatic or unresectable GISTs.
Bibliography:ObjectType-Case Study-2
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ISSN:1130-0108
DOI:10.4321/S1130-01082010000600010