Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson’s disease

• Published in: Brain (London, England : 1878) Vol. 139; no. 8; pp. 2224 - 2234
• Main Authors: Rolinski, Michal, Griffanti, Ludovica, Piccini, Paola, Roussakis, Andreas A., Szewczyk-Krolikowski, Konrad, Menke, Ricarda A., Quinnell, Timothy, Zaiwalla, Zenobia, Klein, Johannes C., Mackay, Clare E., Hu, Michele T. M.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.08.2016
• Subjects: Aged; Basal Ganglia Diseases - diagnostic imaging; Basal Ganglia Diseases - metabolism; Basal Ganglia Diseases - physiopathology; Female; Functional Neuroimaging - methods; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Original; Parkinson Disease - diagnostic imaging; Parkinson Disease - metabolism; Parkinson Disease - physiopathology; REM Sleep Behavior Disorder - diagnostic imaging; REM Sleep Behavior Disorder - metabolism; REM Sleep Behavior Disorder - physiopathology; Tomography, Emission-Computed, Single-Photon; imaging; rapid eye movement sleep behaviour disorder; Parkinson’s disease
• ISSN: 0006-8950; 1460-2156
• DOI: 10.1093/brain/aww124

SEE POSTUMA DOI101093/AWW131 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Resting state functional magnetic resonance imaging dysfunction within the basal ganglia network is a feature of early Parkinson's disease and may be a diagnostic biomarker of basal ganglia dysfunction. Currently, it is u...