Plasma proteome-wide Mendelian randomization reveals the association of extracellular matrix proteins with abdominal aortic aneurysm

• Published in: JVS-vascular science Vol. 6; p. 100290
• Main Authors: Khodursky, Samuel, Yuan, Shuai, Spin, Joshua M., Tsao, Philip S., Levin, Michael G., Damrauer, Scott M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2025; Elsevier
• Subjects: AAA; COL6A3; ECM; LTBP4; Mendelian randomization; LTBP4; AAA; COL6A3; Mendelian randomization; ECM

Abdominal aortic aneurysm (AAA) is a common and life-threatening vascular disease. Genetic studies have identified numerous risk loci, many potentially encoding plasma proteins. However, the causal effects of plasma proteins on AAAs have not been thoroughly studied. We used genetic causal inference...