Pharmacological Evaluation of Dotinurad, a Selective Urate Reabsorption Inhibitor

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 371; no. 1; pp. 162 - 170
• Main Authors: Taniguchi, Tetsuya, Ashizawa, Naoki, Matsumoto, Koji, Saito, Ryo, Motoki, Keisuke, Sakai, Miku, Chikamatsu, Noriko, Hagihara, Chiharu, Hashiba, Masamichi, Iwanaga, Takashi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2019
• Subjects: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2 - antagonists & inhibitors; ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism; Benzothiazoles - adverse effects; Benzothiazoles - pharmacokinetics; Benzothiazoles - pharmacology; Drug Evaluation, Preclinical; Haplorhini; HEK293 Cells; Humans; Male; Neoplasm Proteins - antagonists & inhibitors; Neoplasm Proteins - metabolism; Organic Anion Transport Protein 1 - antagonists & inhibitors; Organic Anion Transport Protein 1 - metabolism; Organic Anion Transporters - antagonists & inhibitors; Organic Anion Transporters - metabolism; Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors; Organic Anion Transporters, Sodium-Independent - metabolism; Organic Cation Transport Proteins - antagonists & inhibitors; Organic Cation Transport Proteins - metabolism; Protein Binding; Rats; Rats, Sprague-Dawley; Uric Acid - blood; Uric Acid - urine; Uricosuric Agents - adverse effects; Uricosuric Agents - pharmacokinetics; OAT; SNP; URAT1; MC; FEUA; HBSS; dotinurad; HPLC; SURI; ABCG2; AUC

The effect of dotinurad [(3,5-dichloro-4-hydroxyphenyl)(1,1-dioxo-1,2-dihydro-3H-1λ6-1,3-benzothiazol-3-yl)methanone] was compared with that of commercially available uricosuric agents—namely, benzbromarone, lesinurad, and probenecid. Its effect on urate secretion transporters was evaluated using pr...