Pharmacological Evaluation of Dotinurad, a Selective Urate Reabsorption Inhibitor - Taniguchi, Tetsuya; Ashizawa, Naoki; Matsumoto, Koji; Saito, Ryo; Motoki, Keisuke; Sakai, Miku; Chikamatsu, Noriko; Hagihara, Chiharu; Hashiba, Masamichi; Iwanaga, Takashi (The Journal of pharmacology and experimental therapeutics, 2019)
Keywords: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2 - antagonists & inhibitors; ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism; Benzothiazoles - adverse effects; Benzothiazoles - pharmacokinetics; Benzothiazoles - pharmacology; Drug Evaluation, Preclinical; Haplorhini; HEK293 Cells; Humans; Male; Neoplasm Proteins - antagonists & inhibitors; Neoplasm Proteins - metabolism; Organic Anion Transport Protein 1 - antagonists & inhibitors; Organic Anion Transport Protein 1 - metabolism; Organic Anion Transporters - antagonists & inhibitors; Organic Anion Transporters - metabolism; Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors; Organic Anion Transporters, Sodium-Independent - metabolism; Organic Cation Transport Proteins - antagonists & inhibitors; Organic Cation Transport Proteins - metabolism; Protein Binding; Rats; Rats, Sprague-Dawley; Uric Acid - blood; Uric Acid - urine; Uricosuric Agents - adverse effects; Uricosuric Agents - pharmacokinetics; OAT; SNP; URAT1; MC; FEUA; HBSS; dotinurad; HPLC; SURI; ABCG2; AUC