Dopamine receptor mechanism(s) and morphine tolerance in mice

• Published in: Journal of psychopharmacology (Oxford) Vol. 16; no. 3; p. 261
• Main Authors: Zarrindast, Mohammad-Reza, Dinkoub, Zahra, Homayoun, Houman, Bakhtiarian, Azam, Khavandgar, Simin
• Format: Journal Article
• Language: English
• Published: United States 01.09.2002
• Subjects: Animals; Dopamine Agonists - pharmacology; Dopamine Antagonists - pharmacology; Drug Tolerance; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine - pharmacology; Pain Threshold - drug effects; Pain Threshold - physiology; Quinpirole - pharmacology; Receptors, Dopamine D2 - drug effects; Receptors, Dopamine D2 - physiology; Sulpiride - pharmacology

Based on our previous demonstration of the involvement of dopamine-2 (D2) dopamine receptors in morphine antinociception, we examined the role of D2 dopamine receptors in the expression and development of tolerance to morphine antinociception in mice. Tolerance to morphine antinociception was assess...