Polymorphisms in NEIL-2, APE-1, CYP2E1 and MDM2 Genes are Independent Predictors of Gastric Cancer Risk in a Northern Jiangsu Population (China)

• Published in: Journal of nanoscience and nanotechnology Vol. 15; no. 7; p. 4815
• Main Authors: Elingarami, Sauli, Liu, Hongna, Kalinjuma, Aneth Vedastus, Hu, Weiyue, Li, Song, He, Nongyue
• Format: Journal Article
• Language: English
• Published: United States 01.07.2015
• Subjects: Adult; Aged; Aged, 80 and over; Alleles; Asian Continental Ancestry Group; Case-Control Studies; China - epidemiology; Cytochrome P-450 CYP2E1 - biosynthesis; Cytochrome P-450 CYP2E1 - genetics; DNA Glycosylases - biosynthesis; DNA Glycosylases - genetics; DNA-(Apurinic or Apyrimidinic Site) Lyase - biosynthesis; DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics; Female; Gene Expression Regulation; Gene Frequency; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins c-mdm2 - biosynthesis; Proto-Oncogene Proteins c-mdm2 - genetics; Stomach Neoplasms - epidemiology; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology

China is one of the countries with the highest incidence of gastric cancer, and accounts for over 40% of all new gastric cancer cases in the world. Genetic factors as well as environmental factors play a role in development of gastric cancer. To investigate the independent roles of single nucleotide...