A multi-omic atlas of the human frontal cortex for aging and Alzheimer’s disease research

• Published in: Scientific data Vol. 5; no. 1; p. 180142
• Main Authors: De Jager, Philip L., Ma, Yiyi, McCabe, Cristin, Xu, Jishu, Vardarajan, Badri N., Felsky, Daniel, Klein, Hans-Ulrich, White, Charles C., Peters, Mette A., Lodgson, Ben, Nejad, Parham, Tang, Anna, Mangravite, Lara M., Yu, Lei, Gaiteri, Chris, Mostafavi, Sara, Schneider, Julie A., Bennett, David A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.08.2018; Nature Publishing Group
• Subjects: 631/1647/2210/2212; 631/1647/2210/2213; 631/1647/514/1948; 631/1647/514/1949; 692/699/375/132/1283; Acetylation; Aged; Aged, 80 and over; Aging; Alzheimer Disease - genetics; Alzheimer Disease - physiopathology; Alzheimer's disease; Chromatin; Chromatin Immunoprecipitation; Cognitive ability; Cortex (frontal); Data Descriptor; Dementia disorders; DNA Methylation; DNA sequencing; Female; Frontal Lobe - physiology; Genome, Human; Genomes; Genotypes; Humanities and Social Sciences; Humans; Immunoprecipitation; Lysine; Male; Memory; Metabolome; Metabolomics; miRNA; multidisciplinary; Nervous system; Neurodegenerative diseases; Phenotypes; Phenotyping; Prefrontal cortex; Proteomics; Science; Sequence Analysis, RNA

We initiated the systematic profiling of the dorsolateral prefrontal cortex obtained from a subset of autopsied individuals enrolled in the Religious Orders Study (ROS) or the Rush Memory and Aging Project (MAP), which are jointly designed prospective studies of aging and dementia with detailed, lon...