Carfilzomib inhibits the growth of lung adenocarcinoma via upregulation of Gadd45a expression

• Published in: Journal of Zhejiang University. B. Science Vol. 21; no. 1; pp. 64 - 76
• Main Authors: Yang, Fang, Liu, Wang-wang, Chen, Hui, Zhu, Jia, Huang, Ai-hua, Zhou, Fei, Gan, Yi, Zhang, Yan-hua, Ma, Li
• Format: Journal Article
• Language: English
• Published: Hangzhou Zhejiang University Press 2020; Springer Nature B.V
• Subjects: Adenocarcinoma; AKT protein; Apoptosis; Biomedical and Life Sciences; Biomedicine; Cell cycle; Cell growth; Cell proliferation; Cytotoxicity; Environmental stress; Flow cytometry; FOXO3 protein; Gadd45A protein; Gene expression; Inhibitors; Kinases; Lung cancer; Lungs; Neoplasia; Proteasome inhibitors; Solid tumors; Targeted cancer therapy; Toxicity; Tumors; Up-regulation; R734.2; Carfilzomib; Cell cycle arrest; 细胞周期阻滞; Gadd45a; Lung adenocarcinoma; 卡非佐米 (Carfilzomib); 凋亡; Apoptosis; 肺腺癌; Carfilzomib; Lung adenocarcinoma; Gadd45a; Cell cycle arrest; Apoptosis

Proteasome inhibitors have shown remarkable success in the treatment of hematologic neoplasm. There has been a lot of attention to applying these drugs for solid tumor treatment. Recent preclinical study has signified the effectiveness on cell proliferation inhibition in lung adenocarcinoma treated...