A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis

• Published in: The New England journal of medicine Vol. 363; no. 7; pp. 609 - 619
• Main Authors: Cooper, Bruce A, Branley, Pauline, Bulfone, Liliana, Collins, John F, Craig, Jonathan C, Fraenkel, Margaret B, Harris, David C, Harris, Anthony, Johnson, David W, Kesselhut, Joan, Li, Jing Jing, Luxton, Grant, Pilmore, Andrew, Tiller, David J, Pollock, Carol A
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 12.08.2010
• Subjects: Adult; Cardiovascular Diseases - etiology; Cardiovascular Diseases - mortality; Clinical medicine; Female; Follow-Up Studies; Glomerular Filtration Rate; Hemodialysis; Humans; Infection - etiology; Infection - mortality; Kaplan-Meier Estimate; Kidney diseases; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - mortality; Kidney Failure, Chronic - therapy; Male; Middle Aged; Proportional Hazards Models; Quality of Life; Renal Dialysis - adverse effects; Renal Dialysis - methods; Statistical analysis; Time Factors; Uremia - etiology

In this study, adults with progressive chronic kidney disease and an estimated glomerular filtration rate between 10 and 15 ml per minute per 1.73 m 2 (stage V chronic kidney disease) were randomly assigned to early or late initiation of dialysis. Early initiation of dialysis was not associated with...