Modulation of P-Glycoprotein at the Blood-Brain Barrier: Opportunities to Improve Central Nervous System Pharmacotherapy

• Published in: Pharmacological reviews Vol. 60; no. 2; pp. 196 - 209
• Main Authors: Miller, David S, Bauer, Björn, Hartz, Anika M S
• Format: Journal Article
• Language: English
• Published: United States American Society for Pharmacology and Experimental Therapeutics 01.06.2008
• Subjects: Animals; ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism; ATP-Binding Cassette, Sub-Family B, Member 1 - physiology; Biological Transport; Blood-Brain Barrier - metabolism; Brain - blood supply; Brain Ischemia - metabolism; Brain Neoplasms - metabolism; Central Nervous System Agents - pharmacology; Encephalitis - metabolism; HIV Infections - metabolism; Humans; Immunity, Innate; Microcirculation - metabolism; Neurodegenerative Diseases - metabolism; Seizures - metabolism; Signal Transduction

Pharmacotherapy of central nervous system (CNS) disorders (e.g., neurodegenerative diseases, epilepsy, brain cancer, and neuro-AIDS) is limited by the blood-brain barrier. P-glycoprotein, an ATP-driven, drug efflux transporter, is a critical element of that barrier. High level of expression, luminal...