Apical Oxidative Hyaluronan Degradation Stimulates Airway Ciliary Beating via RHAMM and RON

• Published in: American journal of respiratory cell and molecular biology Vol. 37; no. 2; pp. 160 - 168
• Main Authors: Manzanares, Dahis, Monzon, Maria-Elena, Savani, Rashmin C, Salathe, Matthias
• Format: Journal Article
• Language: English
• Published: United States Am Thoracic Soc 01.08.2007; American Thoracic Society
• Subjects: Animals; Antibodies - metabolism; Cell Polarity; Cells, Cultured; Cilia - metabolism; Extracellular Matrix Proteins - metabolism; Hepatocyte Growth Factor - genetics; Hepatocyte Growth Factor - metabolism; Humans; Hyaluronan Receptors - metabolism; Hyaluronic Acid - metabolism; Oxidation-Reduction; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; Reactive Oxygen Species - metabolism; Receptor Protein-Tyrosine Kinases - metabolism; Respiratory Mucosa - cytology; Respiratory Mucosa - metabolism; Trachea - anatomy & histology; Xanthine - metabolism; Xanthine Oxidase - metabolism

Hyaluronan (HA) is synthesized in high-molecular-weight form at the apical pole of airway epithelial cells, covering the luminal surface. When human airway epithelial cells grown and redifferentiated at the air-liquid interface (ALI) were exposed to xanthine/xanthine oxidase (X/XO), ciliary beat fre...