Bimodal expression of Wnt5a in the tooth germ: A comparative study using in situ hybridization and immunohistochemistry

• Published in: Annals of Anatomy - Anatomischer Anzeiger Vol. 240; p. 151868
• Main Authors: Sunohara, Masataka, Morikawa, Shigeru, Asada, Naomi, Suzuki, Kingo
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.02.2022; Elsevier BV
• Subjects: Animals; Gene Expression Regulation, Developmental; Immunohistochemistry; In Situ Hybridization; Mice; Odontoblast; Prenatal mouse; Spatiotemporal gene expression; Tooth; Tooth development; Tooth Germ; Wnt-5a Protein; Wnt-5a Protein - genetics; Wnt5a; Immunohistochemistry; Spatiotemporal gene expression; Wnt5a; Tooth development; Prenatal mouse; Odontoblast; In situ hybridization

•Mesenchymal cells undergo bimodal expression of Wnt5a during tooth development.•Undifferentiated mesenchymal cells express abundant Wnt5a mRNA but few proteins.•Apical accumulation of Wnt5a proteins occurs in differentiating odontoblasts about at E18.5. [Display omitted] During tooth development, W...