Effect of Memantine on Cough Reflex Sensitivity: Translational Studies in Guinea Pigs and Humans

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 352; no. 3; pp. 448 - 454
• Main Authors: Dicpinigaitis, Peter V., Canning, Brendan J., Garner, Rachel, Paterson, Blake
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2015
• Subjects: Adult; Animals; Antitussive Agents - pharmacology; Antitussive Agents - therapeutic use; Cough - diagnosis; Cough - drug therapy; Cough - physiopathology; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Guinea Pigs; Humans; Male; Memantine - pharmacology; Memantine - therapeutic use; Translational Research, Biomedical - methods; Treatment Outcome; NMDA; URI; C5

Cough is the most common complaint for which outpatients in the United States seek medical attention, and yet available therapeutic options for cough lack proven efficacy and are further limited by safety and abuse liabilities. Thus, safe and effective cough suppressants are needed. Recent preclinic...