Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population

• Published in: Diabetologia Vol. 50; no. 5; pp. 980 - 984
• Main Authors: Hayashi, T, Iwamoto, Y, Kaku, K, Hirose, H, Maeda, S
• Format: Journal Article
• Language: English
• Published: Berlin Berlin/Heidelberg : Springer-Verlag 01.05.2007; Springer; Springer Nature B.V
• Subjects: Aged; analysis; Asian Continental Ancestry Group; Asian People; Association study; Biological and medical sciences; blood; Chemical research; Diabetes; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - genetics; Diabetes. Impaired glucose tolerance; DNA; DNA - blood; DNA - genetics; DNA - isolation & purification; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; epidemiology; Ethnic Groups - statistics & numerical data; Ethnicity; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Gene polymorphism; Genetic Linkage; Genetic Predisposition to Disease; Genetic testing; genetics; Genotype; Glucose; Glycated Hemoglobin; Glycated Hemoglobin A - analysis; Humans; Internal medicine; isolation & purification; Japan; Japan - epidemiology; Male; Medical sciences; Medicine; Microsatellite marker; Middle Aged; noninsulin-dependent diabetes mellitus; Polymorphism; Polymorphism, Single Nucleotide; Risk Assessment; statistics & numerical data; TCF Transcription Factors; TCF Transcription Factors - genetics; TCF7L2; Transcription factor 7-like 2; Transcription Factor 7-Like 2 Protein; Transcription factors; United States > US; Japan; Endocrinopathy; Type 2 diabetes; TCF7L2; Association study; Metabolic diseases; Transcription factor 7-like 2; Japanese; Gene polymorphism; Sensitivity; Association; Gene; Replication; Microsatellite marker; Transcription factor; Polymorphism

Aims/hypothesis The transcription factor 7-like 2 gene (TCF7L2) has been shown to be strongly associated with an increased risk of type 2 diabetes in white populations. To further investigate the involvement of TCF7L2 in conferring susceptibility to type 2 diabetes, we examined the association of TC...