Identification of WTAP, a novel Wilms' tumour 1-associating protein

• Published in: Human molecular genetics Vol. 9; no. 15; pp. 2231 - 2239
• Main Authors: LITTLE, Natalie A, HASTIE, Nicholas D, DAVIES, Rachel C
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 22.09.2000; Oxford Publishing Limited (England)
• Subjects: Amino Acid Sequence; Animals; Biological and medical sciences; Carrier Proteins - genetics; Carrier Proteins - metabolism; Chromosome Mapping; Chromosomes, Human, Pair 6; Classical genetics, quantitative genetics, hybrids; DNA-Binding Proteins - metabolism; Fundamental and applied biological sciences. Psychology; Genes, Wilms Tumor; Genetics of eukaryotes. Biological and molecular evolution; Human; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Kidney Neoplasms - genetics; Kidney Neoplasms - metabolism; Kidneys; Medical sciences; Mice; Molecular Sequence Data; Nephrology. Urinary tract diseases; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Organ Specificity; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Transcription Factors - metabolism; Tumors of the urinary system; Wilms Tumor - genetics; Wilms Tumor - metabolism; Wilms' tumor; Wilms' tumor 1-associating protein; WT1 gene; WT1 Proteins; WTAP protein; Kidney disease; Genetic mapping; Human; Urinary system disease; Nucleotide sequence; Gene product; Cell nucleus; Rodentia; Homology; Molecular interaction; Malignant tumor; Chromosome C6; Gene expression; Vertebrata; Mammalia; Mouse; Wilms tumor; Localization; Chromosome 17

The Wilms' tumour suppressor gene WT1 is essential for the normal development of the genitourinary system. It appears to play a role in both transcriptional and post-transcriptional regulation of certain cellular genes. However, the mechanisms behind WT1 function are not clearly understood desp...