Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis

• Published in: Nutrients Vol. 13; no. 10; p. 3509
• Main Authors: Sehgal, Ratika, Ilha, Mariana, Vaittinen, Maija, Kaminska, Dorota, Männistö, Ville, Kärjä, Vesa, Tuomainen, Marjo, Hanhineva, Kati, Romeo, Stefano, Pajukanta, Päivi, Pihlajamäki, Jussi, de Mello, Vanessa D.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 05.10.2021; MDPI
• Subjects: bariatric surgery; Biopsy; Body mass index; cell adhesion; Cell adhesion & migration; cell movement; Clinical Medicine; Cytotoxicity; Extracellular matrix; Fatty liver; fibrosis; Gastrointestinal surgery; Gene expression; Gut microbiota; Hepatic fibrosis; Hepatic stellate cells; hepatoprotective effect; Histology; human health; humans; Indole-3-propionic acid; Inflammation; Klinisk medicin; Liver; liver cirrhosis; Metabolism; Metabolites; Non-alcoholic fatty liver disease; noninsulin-dependent diabetes mellitus; obesity; Physiology; rodents; sequence analysis; transcriptomics; tryptophan; United States > US; Germany

Background and Aims: Gut microbiota-derived metabolites play a vital role in maintenance of human health and progression of disorders, including obesity and type 2 diabetes (T2D). Indole-3-propionic acid (IPA), a gut-derived tryptophan metabolite, has been recently shown to be lower in individuals w...