Adolescent intermittent ethanol (AIE) sensitized fever in male Sprague Dawley rats exposed to poly I:C in adulthood

• Published in: Brain, behavior, and immunity Vol. 120; pp. 82 - 97
• Main Authors: Gano, Anny, Wojcik, Hannah, Danseglio, Nina C., Kelliher, Kaitlyn, Varlinskaya, Elena I., Deak, Terrence
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.08.2024
• Subjects: Adolescence; AIE; Animals; Brain; Ethanol - administration & dosage; Ethanol - pharmacology; Female; Fever; Fever - chemically induced; IL-1; Intermittent ethanol exposure; Male; Neuroimmune; Poly I-C; Rats; Rats, Sprague-Dawley; Sex differences; TLR3; Adolescence; Brain; IL-1; Intermittent ethanol exposure; Neuroimmune; Sex differences; Poly I:C; AIE; Fever; TLR3

•Ethanol-naïve males and females showed similar fever response to 4 mg/kg poly I:C.•This fever response was enhanced in adult males but not females with a history of AIE.•AIE sensitized central cytokine response to poly I:C in adult male NTS.•AIE did not affect adult female responsiveness to poly I:...