Novel Polymorphisms in the Myosin Light Chain Kinase Gene Confer Risk for Acute Lung Injury

• Published in: American journal of respiratory cell and molecular biology Vol. 34; no. 4; pp. 487 - 495
• Main Authors: Gao, Li, Grant, Audrey, Halder, Indrani, Brower, Roy, Sevransky, Jonathan, Maloney, James P, Moss, Marc, Shanholtz, Carl, Yates, Charles R, Meduri, Gianfranco Umberto, Shriver, Mark D, Ingersoll, Roxann, Scott, Alan F, Beaty, Terri H, Moitra, Jaideep, Ma, Shwu Fan, Ye, Shui Q, Barnes, Kathleen C, Garcia, Joe G. N
• Format: Journal Article
• Language: English
• Published: United States Am Thoracic Soc 01.04.2006; American Thoracic Society
• Subjects: Adolescent; Adult; Aged; Black or African American; Case-Control Studies; Exons; Female; Haplotypes; Humans; Introns; Linkage Disequilibrium; Male; Middle Aged; Myosin-Light-Chain Kinase - genetics; Polymorphism, Single Nucleotide; Protein Isoforms - genetics; Respiratory Distress Syndrome - etiology; Respiratory Distress Syndrome - genetics; Risk; Sepsis - complications; Sepsis - genetics; White People

The genetic basis of acute lung injury (ALI) is poorly understood. The myosin light chain kinase (MYLK) gene encodes the nonmuscle myosin light chain kinase isoform, a multifunctional protein involved in the inflammatory response (apoptosis, vascular permeability, leukocyte diapedesis). To examine M...