Safety and Efficacy of Vaptans in the Treatment of Hyponatremia from Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): A Systematic Review and Meta-Analysis

• Published in: Journal of clinical medicine Vol. 12; no. 17; p. 5483
• Main Authors: Krisanapan, Pajaree, Tangpanithandee, Supawit, Thongprayoon, Charat, Pattharanitima, Pattharawin, Kleindienst, Andrea, Miao, Jing, Craici, Iasmina M., Mao, Michael A., Cheungpasitporn, Wisit
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 24.08.2023; MDPI
• Subjects: Antagonists (Biochemistry); Clinical medicine; Cohort analysis; Confidence intervals; Drug dosages; Drug therapy; Hyponatremia; Meta-analysis; Patient outcomes; Sodium; Systematic Review; Testing; Vasopressin; Thailand; United States > US

The utilization of vasopressin receptor antagonists, known as vaptans, in the management of hyponatremia among patients afflicted with the syndrome of inappropriate antidiuretic hormone (SIADH) remains a contentious subject. This meta-analysis aimed to evaluate the safety and efficacy of vaptans for...