Franz Cell Diffusion Testing and Quantitative Confocal Raman Spectroscopy: In Vitro-In Vivo Correlation

• Published in: Pharmaceutics Vol. 12; no. 9; p. 887
• Main Authors: Iliopoulos, Fotis, Caspers, Peter J., Puppels, Gerwin J., Lane, Majella E.
• Format: Journal Article
• Language: English
• Published: MDPI 18.09.2020; MDPI AG
• Subjects: bioequivalence; Communication; Confocal Raman Spectroscopy; in vitro-in vivo correlation; niacinamide; skin

Previously, we reported the use of Confocal Raman Spectroscopy (CRS) to investigate the topical delivery of actives and excipients. We have also correlated the results from CRS with findings from in vitro diffusion studies in human skin. However, until now CRS has only been used as a semi-quantitati...