Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 368; no. 1; pp. 136 - 145
• Main Authors: Shen, Hong, Holenarsipur, Vinay K., Mariappan, T. Thanga, Drexler, Dieter M., Cantone, Joseph L., Rajanna, Prabhakar, Singh Gautam, Shashyendra, Zhang, Yueping, Gan, Jinping, Shipkova, Petia A., Marathe, Punit, Humphreys, W. Griffith
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2019
• Subjects: Adolescent; Adult; Biomarkers - blood; Cross-Over Studies; Healthy Volunteers; Humans; Male; Middle Aged; Organic Anion Transport Protein 1 - physiology; Organic Anion Transporters, Sodium-Independent - physiology; Pyridoxic Acid - blood; Reproducibility of Results; Young Adult; GCDCA-S; OCT; Km; OAT; DMSO; CLR; DDI; MRP; DP; PDA; AUC; Cmin; fu; LC-MS/MS; 6βHC; AUC0-last; m/z; CLsec; HPLC; FSM; CE; CI; MATE; T1/2; IS; OATP; PROB; RED; HVA; AUC0-; Tmax; AUCR; CL/F

Plasma pyridoxic acid (PDA) and homovanillic acid (HVA) were recently identified as novel endogenous biomarkers of organic anion transporter (OAT) 1/3 function in monkeys. Consequently, this clinical study assessed the dynamic changes and utility of plasma PDA and HVA as an initial evaluation of OAT...