Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects - Shen, Hong; Holenarsipur, Vinay K.; Mariappan, T. Thanga; Drexler, Dieter M.; Cantone, Joseph L.; Rajanna, Prabhakar; Singh Gautam, Shashyendra; Zhang, Yueping; Gan, Jinping; Shipkova, Petia A.; Marathe, Punit; Humphreys, W. Griffith (The Journal of pharmacology and experimental therapeutics, 2019)
Keywords: Adolescent; Adult; Biomarkers - blood; Cross-Over Studies; Healthy Volunteers; Humans; Male; Middle Aged; Organic Anion Transport Protein 1 - physiology; Organic Anion Transporters, Sodium-Independent - physiology; Pyridoxic Acid - blood; Reproducibility of Results; Young Adult; GCDCA-S; OCT; Km; OAT; DMSO; CLR; DDI; MRP; DP; PDA; AUC; Cmin; fu; LC-MS/MS; 6βHC; AUC0-last; m/z; CLsec; HPLC; FSM; CE; CI; MATE; T1/2; IS; OATP; PROB; RED; HVA; AUC0-; Tmax; AUCR; CL/F