Thiazolidinediones Regulate Adipose Lineage Dynamics
White adipose tissue regulates metabolism; the importance of this control is highlighted by the ongoing pandemic of obesity and associated complications such as diabetes, atherosclerosis, and cancer. White adipose tissue maintenance is a dynamic process, yet very little is known about how pharmacolo...
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| Published in | Cell metabolism Vol. 14; no. 1; pp. 116 - 122 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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United States
Elsevier Inc
06.07.2011
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| Abstract | White adipose tissue regulates metabolism; the importance of this control is highlighted by the ongoing pandemic of obesity and associated complications such as diabetes, atherosclerosis, and cancer. White adipose tissue maintenance is a dynamic process, yet very little is known about how pharmacologic stimuli affect such plasticity. Combining in vivo lineage marking and BrdU labeling strategies, we found that rosiglitazone, a member of the thiazolidinedione class of glucose-lowering medicines, markedly increases the evolution of adipose progenitors into adipocytes. Notably, chronic rosiglitazone administration disrupts the adipogenic and self-renewal capacities of the stem cell compartment and alters its molecular characteristics. These data unravel unknown aspects of adipose dynamics and provide a basis to manipulate the adipose lineage for therapeutic ends.
► Thiazolidinediones (TZDs) stimulate new adipocyte formation in white adipose tissue ► TZDs stimulate the proliferation and differentiation of adipose progenitors ► Chronic TZD treatment disrupts the progenitor properties ► TZDs alter the molecular characteristics of adipose progenitors |
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| AbstractList | White adipose tissue regulates metabolism; the importance of this control is highlighted by the ongoing pandemic of obesity and associated complications such as diabetes, atherosclerosis, and cancer. White adipose tissue maintenance is a dynamic process, yet very little is known about how pharmacologic stimuli affect such plasticity. Combining
in vivo
lineage marking and BrdU labeling strategies, we found that rosiglitazone, a member of the thiazolidinedione class of glucose-lowering medicines, markedly increases the evolution of adipose progenitors into adipocytes. Notably, chronic rosiglitazone administration disrupts the adipogenic and self-renewal capacities of the stem cell compartment and alters its molecular characteristics. These data unravel unknown aspects of adipose dynamics and provide a basis to manipulate the adipose lineage for therapeutic ends. White adipose tissue regulates metabolism; the importance of this control is highlighted by the ongoing pandemic of obesity and associated complications such as diabetes, atherosclerosis, and cancer. White adipose tissue maintenance is a dynamic process, yet very little is known about how pharmacologic stimuli affect such plasticity. Combining in vivo lineage marking and BrdU labeling strategies, we found that rosiglitazone, a member of the thiazolidinedione class of glucose-lowering medicines, markedly increases the evolution of adipose progenitors into adipocytes. Notably, chronic rosiglitazone administration disrupts the adipogenic and self-renewal capacities of the stem cell compartment and alters its molecular characteristics. These data unravel unknown aspects of adipose dynamics and provide a basis to manipulate the adipose lineage for therapeutic ends. ► Thiazolidinediones (TZDs) stimulate new adipocyte formation in white adipose tissue ► TZDs stimulate the proliferation and differentiation of adipose progenitors ► Chronic TZD treatment disrupts the progenitor properties ► TZDs alter the molecular characteristics of adipose progenitors White adipose tissue regulates metabolism; the importance of this control is highlighted by the ongoing pandemic of obesity and associated complications such as diabetes, atherosclerosis, and cancer. White adipose tissue maintenance is a dynamic process, yet very little is known about how pharmacologic stimuli affect such plasticity. Combining in vivo lineage marking and BrdU labeling strategies, we found that rosiglitazone, a member of the thiazolidinedione class of glucose-lowering medicines, markedly increases the evolution of adipose progenitors into adipocytes. Notably, chronic rosiglitazone administration disrupts the adipogenic and self-renewal capacities of the stem cell compartment and alters its molecular characteristics. These data unravel unknown aspects of adipose dynamics and provide a basis to manipulate the adipose lineage for therapeutic ends. |
| Author | Graff, Jonathan M. Seo, Jin Zeve, Daniel Tang, Wei Jo, A-Young |
| AuthorAffiliation | 2 Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., NB5.118, Dallas, Texas 75390-9133, USA 1 Department of Developmental Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., NB5.118, Dallas, Texas 75390-9133, USA |
| AuthorAffiliation_xml | – name: 1 Department of Developmental Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., NB5.118, Dallas, Texas 75390-9133, USA – name: 2 Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., NB5.118, Dallas, Texas 75390-9133, USA |
| Author_xml | – sequence: 1 givenname: Wei surname: Tang fullname: Tang, Wei organization: Department of Developmental Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, NB5.118, Dallas, TX 75390-9133, USA – sequence: 2 givenname: Daniel surname: Zeve fullname: Zeve, Daniel organization: Department of Developmental Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, NB5.118, Dallas, TX 75390-9133, USA – sequence: 3 givenname: Jin surname: Seo fullname: Seo, Jin organization: Department of Developmental Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, NB5.118, Dallas, TX 75390-9133, USA – sequence: 4 givenname: A-Young surname: Jo fullname: Jo, A-Young organization: Department of Developmental Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, NB5.118, Dallas, TX 75390-9133, USA – sequence: 5 givenname: Jonathan M. surname: Graff fullname: Graff, Jonathan M. email: jon.graff@utsouthwestern.edu organization: Department of Developmental Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, NB5.118, Dallas, TX 75390-9133, USA |
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| Title | Thiazolidinediones Regulate Adipose Lineage Dynamics |
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