Interplay of formulation and process methodology on the extent of nifedipine molecular dispersion in polymers

• Published in: International journal of pharmaceutics Vol. 420; no. 1; pp. 59 - 67
• Main Authors: Huang, Jingjun, Li, Ying, Wigent, Rodney J., Malick, Waseem A., Sandhu, Harpreet K., Singhal, Dharmendra, Shah, Navnit H.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25.11.2011
• Subjects: Amorphous solid dispersion; Calorimetry, Differential Scanning; Cellulose - analogs & derivatives; Cellulose - chemistry; Chemical Precipitation; Chemistry, Pharmaceutical; coprecipitation; Crystallography, X-Ray; dispersibility; dispersions; Drug Carriers; Drug Compounding; drugs; Drug–polymer interactions; Formulation; Fourier transform infrared spectroscopy; glass transition; Kinetics; Molecular dispersibility; Nifedipine - chemistry; polymers; Polymers - chemistry; Powder Diffraction; Process technology; processing technology; solidification; Solubility; Solvents - chemistry; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical - methods; thermodynamics; Transition Temperature; Amorphous solid dispersion; Process technology; Drug–polymer interactions; Molecular dispersibility; Formulation

The aim of this study is to evaluate effects of formulation and process technology on drug molecular dispersibility in solid dispersions (SDs). Nifedipine solid dispersions with ethylcellulose (EC) and/or Eudragit RL (RL) prepared by co-precipitation, co-evaporation, and fusion methods were characte...