Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells

• Published in: American journal of physiology. Renal physiology Vol. 309; no. 3; pp. F204 - F215
• Main Authors: Subathra, Marimuthu, Korrapati, Midhun, Howell, Lauren A., Arthur, John M., Shayman, James A., Schnellmann, Rick G., Siskind, Leah J.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.08.2015
• Subjects: Animals; Antigens, CD - metabolism; Cell Line; Cell Proliferation; Diabetes; Diabetes Mellitus, Experimental - pathology; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - pathology; Glycosphingolipids - metabolism; Humans; Kidney - metabolism; Kidney diseases; Kidney Glomerulus - pathology; Kidney Tubules, Proximal - pathology; Lactosylceramides - metabolism; Lipids; Matrix; Mesangial Cells - pathology; Mesangial Cells - ultrastructure; Mice; Oncogene Protein v-akt - metabolism; Proteins; Rodents; Signal Transduction; Smad3 Protein - metabolism; kidney; hypertrophy; mesangial cells; diabetic nephropathy; glycosphingolipids

Glycosphingolipids (GSLs) play a role in insulin resistance and diabetes, but their role in diabetic nephropathy (DN) has received limited attention. We used 9- and 17-wk-old nondiabetic db/ m and diabetic db/ db mice to examine the role of GSLs in DN. Cerebrosides or monoglycosylated GSLs [hexosylc...