Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques

• Published in: Science translational medicine Vol. 3; no. 84; p. 84ra45
• Main Authors: Vinegoni, Claudio, Botnaru, Ion, Aikawa, Elena, Calfon, Marcella A, Iwamoto, Yoshiko, Folco, Eduardo J, Ntziachristos, Vasilis, Weissleder, Ralph, Libby, Peter, Jaffer, Farouc A
• Format: Journal Article
• Language: English
• Published: United States 25.05.2011
• Subjects: Acetylation; Animals; Arteries - pathology; Arteries - physiopathology; Capillary Permeability - physiology; Cattle; Diagnostic Imaging - methods; Endocytosis; Fluorescence; Humans; Indocyanine Green; Inflammation - complications; Inflammation - pathology; Lipids - chemistry; Lipoproteins, LDL - metabolism; Macrophages - metabolism; Macrophages - pathology; Plaque, Atherosclerotic - complications; Plaque, Atherosclerotic - diagnosis; Plaque, Atherosclerotic - diagnostic imaging; Plaque, Atherosclerotic - physiopathology; Rabbits; Radiography; Serum Albumin, Bovine - metabolism; Spectroscopy, Near-Infrared - methods

New high-resolution molecular and structural imaging strategies are needed to visualize high-risk plaques that are likely to cause acute myocardial infarction, because current diagnostic methods do not reliably identify at-risk subjects. Although molecular imaging agents are available for low-resolu...