Alveolar epithelium and Na,K-ATPase in acute lung injury

• Published in: Intensive care medicine Vol. 33; no. 7; pp. 1243 - 1251
• Main Authors: VADASZ, Istvan, RAVIV, Stacy, SZNAJDER, Jacob I
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.07.2007; Berlin Springer Nature B.V; Springer Berlin Heidelberg
• Subjects: Adenosine triphosphatase; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Biological and medical sciences; Edema; Emergency and intensive respiratory care; Epithelium - enzymology; Extravascular Lung Water - metabolism; Humans; Injuries of the thorax. Foreign bodies. Diseases due to physical agents; Intensive care medicine; Lungs; Medical sciences; Mini-series: basic research-related topics in ICM; Proteins; Pulmonary Alveoli - enzymology; Pulmonary Edema - metabolism; Respiratory Distress Syndrome, Adult - drug therapy; Respiratory Distress Syndrome, Adult - enzymology; Signal Transduction; Sodium; Sodium-Potassium-Exchanging ATPase - metabolism; Traumas. Diseases due to physical agents; Edema; Acute lung injury; Oxygen; Intensive care; Dopamine; Respiratory disease; Enzyme; Edema clearance, Hypoxia,Coagulation; K; Catecholamine; Epithelium; Na; Neurotransmitter; Hydrolases; Hypoxia; exchanging ATPase; Resuscitation; Catecholamines,Dopamine; Protein trafficking

Active transport of sodium across the alveolar epithelium, undertaken in part by the Na,K-adenosine triphosphatase (Na,K-ATPase), is critical for clearance of pulmonary edema fluid and thus the outcome of patients with acute lung injury. Acute lung injury results in disruption of the alveolar epithe...