Intratumor genetic heterogeneity in squamous cell carcinoma of the oral cavity

• Published in: Head & neck Vol. 41; no. 8; pp. 2514 - 2524
• Main Authors: Zandberg, Dan P., Tallon, Luke J., Nagaraj, Sushma, Sadzewicz, Lisa K., Zhang, Yuji, Strome, Maxwell B., Zhao, Xuechu E., Vavikolanu, Kranthi, Zhang, Xiaoyu, Papadimitriou, John C., Hubbard, Fleesie A., Bentzen, Søren M., Strome, Scott E., Fraser, Claire M.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.08.2019; Wiley Subscription Services, Inc
• Subjects: Biopsy; genetic; Head & neck cancer; heterogeneity; Mutation; Neck; Oral cavity; p53 Protein; Parenchyma; Precision medicine; SCCHN; Squamous cell carcinoma; Tumors; genetic; SCCHN; oral cavity; heterogeneity; squamous cell carcinoma

Background We sought to evaluate intratumor heterogeneity in squamous cell carcinoma of the oral cavity (OCC) and specifically determine the effect of physical separation and histologic differentiation within the same tumor. Methods We performed whole exome sequencing on five biopsy sites—two from w...