Loss of PRMT1 in the central nervous system (CNS) induces reactive astrocytes and microglia during postnatal brain development

• Published in: Journal of neurochemistry Vol. 156; no. 6; pp. 834 - 847
• Main Authors: Hashimoto, Misuzu, Kumabe, Ayako, Kim, Jun‐Dal, Murata, Kazuya, Sekizar, Sowmya, Williams, Anna, Lu, Weizhe, Ishida, Junji, Nakagawa, Tsutomu, Endo, Mitsuharu, Minami, Yasuhiro, Fukamizu, Akiyoshi
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.03.2021
• Subjects: Animals; Animals, Newborn; Arginine; astrocyte; Astrocytes; Brain; Brain - growth & development; Calcium-Binding Proteins - genetics; Calcium-Binding Proteins - metabolism; Cell lineage; Cell proliferation; Central nervous system; central nervous system (CNS); Central Nervous System - metabolism; Cytokines; Deoxyribonucleic acid; DNA; DNA damage; Encephalitis - physiopathology; Female; Gene expression; Glial fibrillary acidic protein; Gliosis; Inflammation; Interleukin-6 - metabolism; Interleukins; Mice; Mice, Knockout; Microfilament Proteins - genetics; Microfilament Proteins - metabolism; Microglia; Mutation; Myelin Sheath; Myelination; Neonates; Nervous system; Neural stem cells; Neural Stem Cells - metabolism; Neuronal-glial interactions; Phenotypes; Pregnancy; PRMT1; Protein arginine methyltransferase; Protein-Arginine N-Methyltransferases - genetics; Proteins; RNA, Small Interfering - pharmacology; Signal Transduction; Stem cells; Transcription; transcriptome; Vimentin; central nervous system (CNS); PRMT1; inflammation; astrocyte; microglia; transcriptome
• ISSN: 0022-3042; 1471-4159; 1471-4159
• DOI: 10.1111/jnc.15149

PRMT1, a major arginine methyltransferase, plays critical roles in transcription, DNA damage response, and cell proliferation. Although we have previously discovered the crucial roles of PRMT1 for oligodendrocyte lineage progression in the central nervous system of neural stem cell‐specific PRMT1 co...