Parabacteroides distasonis attenuates toll‐like receptor 4 signaling and Akt activation and blocks colon tumor formation in high‐fat diet‐fed azoxymethane‐treated mice

• Published in: International journal of cancer Vol. 143; no. 7; pp. 1797 - 1805
• Main Authors: Koh, Gar Yee, Kane, Anne, Lee, Kyongbum, Xu, Qiaobing, Wu, Xian, Roper, Jatin, Mason, Joel B., Crott, Jimmy W.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.10.2018
• Subjects: AKT protein; Animal models; Animals; Apoptosis; Azoxymethane; Azoxymethane - toxicity; Bacteroidetes - physiology; Cancer; Carcinogens - toxicity; Cell lines; Cell Proliferation; Colon; Colon cancer; Colonic Neoplasms - etiology; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; Colonic Neoplasms - prevention & control; Colorectal cancer; Diet, High-Fat - adverse effects; Dysbacteriosis; High fat diet; Humans; IL-1β; Inflammation; Intestine; Lipopolysaccharides; Low fat diet; Male; Medical research; Mice; Mice, Inbred A; Mucosa; MyD88 protein; Nutrient deficiency; Parabacteroides distasonis; protein kinase B; Proto-Oncogene Proteins c-akt - metabolism; TLR4 protein; Toll-Like Receptor 4 - metabolism; Toll-like receptors; toll‐like receptor 4; Tumor cell lines; Tumor Cells, Cultured; Tumorigenesis; Parabacteroides distasonis; colorectal cancer; inflammation; toll-like receptor 4; protein kinase B

Gut dysbiosis may play an etiological role in colorectal tumorigenesis. We previously observed that the abundance of Parabacteroides distasonis (Pd) in stool was inversely associated with intestinal tumor burden and IL‐1β concentrations in mice. Here, we assessed the anti‐inflammatory capacity of Pd...