Parabacteroides distasonis attenuates toll‐like receptor 4 signaling and Akt activation and blocks colon tumor formation in high‐fat diet‐fed azoxymethane‐treated mice - Koh, Gar Yee; Kane, Anne; Lee, Kyongbum; Xu, Qiaobing; Wu, Xian; Roper, Jatin; Mason, Joel B.; Crott, Jimmy W. (International journal of cancer, 2018)
Keywords: AKT protein; Animal models; Animals; Apoptosis; Azoxymethane; Azoxymethane - toxicity; Bacteroidetes - physiology; Cancer; Carcinogens - toxicity; Cell lines; Cell Proliferation; Colon; Colon cancer; Colonic Neoplasms - etiology; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; Colonic Neoplasms - prevention & control; Colorectal cancer; Diet, High-Fat - adverse effects; Dysbacteriosis; High fat diet; Humans; IL-1β; Inflammation; Intestine; Lipopolysaccharides; Low fat diet; Male; Medical research; Mice; Mice, Inbred A; Mucosa; MyD88 protein; Nutrient deficiency; Parabacteroides distasonis; protein kinase B; Proto-Oncogene Proteins c-akt - metabolism; TLR4 protein; Toll-Like Receptor 4 - metabolism; Toll-like receptors; toll‐like receptor 4; Tumor cell lines; Tumor Cells, Cultured; Tumorigenesis; Parabacteroides distasonis; colorectal cancer; inflammation; toll-like receptor 4; protein kinase B