Chitinase 3‐like 1 drives allergic skin inflammation via Th2 immunity and M2 macrophage activation

• Published in: Clinical and experimental allergy Vol. 49; no. 11; pp. 1464 - 1474
• Main Authors: Kwak, Eun Ji, Hong, Jung Yeon, Kim, Mi Na, Kim, Soo Yeon, Kim, Seo Hyeong, Park, Chang Ook, Kim, Kyung Won, Lee, Chun Geun, Elias, Jack A., Jee, Hye Mi, Sohn, Myung Hyun
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.11.2019
• Subjects: Allergens; Animal models; Apoptosis; Asthma; Atopic dermatitis; Breast; CD4 antigen; Cell activation; Chitinase; chitinase 3‐like 1; Eczema; Enzyme-linked immunosorbent assay; Gene expression; Immunity; Immunofluorescence; Immunoglobulin E; Inflammation; Lymphocytes T; Macrophages; Ovalbumin; Rodents; skin barrier; Skin diseases; type 2 immunity; skin barrier; atopic dermatitis; chitinase 3-like 1; type 2 immunity

Background Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by defective skin barrier and Th2 immune responses. Chitinase 3‐like 1 (CHI3L1), also known as breast regression protein 39 (BRP‐39) in mice and human homologue YKL‐40, plays important roles in Th2 inflammation a...