SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis

• Published in: EBioMedicine Vol. 85; p. 104278
• Main Authors: Wang, Di, Lin, Yunkai, Xu, Feihong, Zhang, Hui, Zhu, Xiaoyan, Liu, Zhen, Hu, Yuan, Dong, Guanjun, Sun, Bingqi, Yu, Yanhong, Ma, Guoren, Tang, Zhigang, Legarda, Diana, Ting, Adrian, Liu, Yuan, Hou, Jia, Dong, Liwei, Xiong, Huabao
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.11.2022; Elsevier
• Subjects: Advanced Basic Science; Autophagy; Biomarker; Immune response; Internal Medicine; Macrophage; Necroptosis; Biomarker; Immune response; Necroptosis; Autophagy; Macrophage

To determine whether SIRPα can be a diagnostic marker of pulmonary tuberculosis (PTB) and the molecular mechanism of SIRPα regulating macrophages to kill Mycobacterium tuberculosis (MTB). Meta-analysis combined with subsequent qRT-PCR, western-blotting and flow cytometry assay were used to detect SI...