Osteocalcin Regulates Arterial Calcification Via Altered Wnt Signaling and Glucose Metabolism

• Published in: Journal of bone and mineral research Vol. 35; no. 2; pp. 357 - 367
• Main Authors: Rashdan, Nabil A, Sim, Alisia M, Cui, Lin, Phadwal, Kanchan, Roberts, Fiona L, Carter, Roderick, Ozdemir, Derya D, Hohenstein, Peter, Hung, John, Kaczynski, Jakub, Newby, David E, Baker, Andrew H, Karsenty, Gerard, Morton, Nicholas M, MacRae, Vicky E
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.02.2020; Oxford University Press
• Subjects: Animals; ARTERIAL CALCIFICATION; Arteriosclerosis; Calcification; Calcification (ectopic); Calcium; Cardiovascular diseases; Carotid artery; Cbfa-1 protein; Cells, Cultured; Cyclin D; Electron transport; Gene expression; Glucose; Glucose metabolism; Immunohistochemistry; Localization; Metabolism; Mice; Mineralization; Mitochondria; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; OSTEOCALCIN; Osteocalcin - genetics; Phosphate transporter; Pit1 protein; Plaques; Respiration; Smooth muscle; Therapeutic applications; Vascular Calcification; Wnt protein; WNT SIGNALING; Wnt Signaling Pathway; OSTEOCALCIN; WNT SIGNALING; ARTERIAL CALCIFICATION

ABSTRACT Arterial calcification is an important hallmark of cardiovascular disease and shares many similarities with skeletal mineralization. The bone‐specific protein osteocalcin (OCN) is an established marker of vascular smooth muscle cell (VSMC) osteochondrogenic transdifferentiation and a known...