Endothelial extracellular vesicles modulate the macrophage phenotype: Potential implications in atherosclerosis

• Published in: Scandinavian journal of immunology Vol. 87; no. 4; pp. e12648 - n/a
• Main Authors: He, S., Wu, C., Xiao, J., Li, D., Sun, Z., Li, M.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.04.2018
• Subjects: Arteriosclerosis; Atherosclerosis; Cell activation; Cell interactions; endothelial cell; Endothelial cells; Exosomes; Extracellular vesicles; Flow cytometry; Homeostasis; Immunofluorescence; Immunomodulation; Inflammation; Krueppel-like factor; Low density lipoprotein; Macrophages; Membrane vesicles; MicroRNAs; miRNA; miR‐155; Monocytes; Phenotypes; Secretion; Umbilical vein; atherosclerosis; macrophages; extracellular vesicles; endothelial cell; miR-155

Endothelial cells (ECs) and macrophages engage in tight and specific interactions that play critical roles in cardiovascular homeostasis and the pathogenesis of atherosclerosis. Extracellular vesicles (EVs) are circular membrane fragments released from the endosomal compartment as exosomes or shed f...